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{
    "metadata": {
        "accession": "IPR019765",
        "entry_id": null,
        "type": "conserved_site",
        "go_terms": [
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "prosite": {
                "PS01299": "Ephrin receptor-binding (ephrin RBD) domain signature"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR019765",
            "name": "Ephrin, conserved site",
            "type": "Conserved_site",
            "children": []
        },
        "name": {
            "name": "Ephrin, conserved site",
            "short": "Ephrin_CS"
        },
        "description": [
            {
                "text": "<p>Ephrins are a family of proteins [[cite:PUB00004495]] that are ligands of class V (EPH-related) receptor protein-tyrosine kinases. These receptors and their ligands have been implicated in regulating neuronal axon guidance and in patterning of the developing nervous system and may also serve a patterning and compartmentalisation role outside of the nervous system as well.</p>\r\n<p>Ephrins are membrane-attached proteins of 205 to 340 residues. Attachment appears to be crucial for their normal function. Type-A ephrins are linked to the membrane via a glycosylphosphatidylinositol (GPI)-linkage, while type-B ephrins are type-I membrane proteins.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00004495": {
                "PMID": 7838529,
                "ISBN": null,
                "volume": "10",
                "issue": "2",
                "year": 1995,
                "title": "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.",
                "URL": null,
                "raw_pages": "299-306",
                "medline_journal": "Oncogene",
                "ISO_journal": "Oncogene",
                "authors": [
                    "Kozlosky CJ",
                    "Maraskovsky E",
                    "McGrew JT",
                    "VandenBos T",
                    "Teepe M",
                    "Lyman SD",
                    "Srinivasan S",
                    "Fletcher FA",
                    "Gayle RB 3rd",
                    "Cerretti DP."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 6452,
            "pathways": 18,
            "proteins": 6448,
            "proteomes": 732,
            "sets": 0,
            "structural_models": {
                "alphafold": 6058,
                "bfvd": 0
            },
            "structures": 28,
            "taxa": 2256
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}