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{
"metadata": {
"accession": "IPR019595",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF10615": "Domain of unknown function (DUF2470)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR019595",
"name": "Domain of unknown function DUF2470",
"type": "Domain",
"children": []
},
"name": {
"name": "Domain of unknown function DUF2470",
"short": "DUF2470"
},
"description": [
{
"text": "<p>This entry represents an uncharacterised domain that can be found in a group of putative haem-iron utilisation proteins, such as HugZ from H. pylori and non-canonical heme oxygenase HOZ form Arabidopsis. HOZ is a dimeric β-barrel protein that binds to heme and catalyses its degradation to produce biliverdin [[cite:PUB00155388]]. This domain can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis [[cite:PUB00075508]]. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis [[cite:PUB00075509]]. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts [[cite:PUB00075510]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00075508": {
"PMID": 24753615,
"ISBN": null,
"volume": "111",
"issue": "18",
"year": 2014,
"title": "Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein.",
"URL": null,
"raw_pages": "6630-5",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Zhao A",
"Fang Y",
"Chen X",
"Zhao S",
"Dong W",
"Lin Y",
"Gong W",
"Liu L."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.1400166111"
},
"PUB00075509": {
"PMID": 22180625,
"ISBN": null,
"volume": "23",
"issue": "12",
"year": 2011,
"title": "An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.",
"URL": null,
"raw_pages": "4476-91",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Czarnecki O",
"Hedtke B",
"Melzer M",
"Rothbart M",
"Richter A",
"Schroter Y",
"Pfannschmidt T",
"Grimm B."
],
"DOI_URL": "http://dx.doi.org/10.1105/tpc.111.086421"
},
"PUB00075510": {
"PMID": 20657737,
"ISBN": null,
"volume": "5",
"issue": "7",
"year": 2010,
"title": "Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for efficient photosynthetic electron transport.",
"URL": null,
"raw_pages": "e11688",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Jung HS",
"Okegawa Y",
"Shih PM",
"Kellogg E",
"Abdel-Ghany SE",
"Pilon M",
"Sjolander K",
"Shikanai T",
"Niyogi KK."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0011688"
},
"PUB00155388": {
"PMID": 33284325,
"ISBN": null,
"volume": null,
"issue": null,
"year": 2020,
"title": "The Arabidopsis locus AT3G03890 encodes a dimeric β-barrel protein implicated in heme degradation.",
"URL": null,
"raw_pages": "BCJ20200712",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem J",
"authors": [
"Wang J",
"Guo Q",
"Li X",
"Wang X",
"Liu L."
],
"DOI_URL": "https://doi.org/10.1042/BCJ20200712"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR037119",
"name": "Haem oxygenase HugZ-like superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 84,
"interactions": 0,
"matches": 9418,
"pathways": 0,
"proteins": 9410,
"proteomes": 5475,
"sets": 0,
"structural_models": {
"alphafold": 7106,
"bfvd": 0
},
"structures": 16,
"taxa": 9973
},
"entry_annotations": {
"alignment:seed": 166,
"alignment:full": 4274
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "8zxq",
"name": "Crystal structure of Ssr1698 in complex with heme b"
}
}
}
