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{
    "metadata": {
        "accession": "IPR019309",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0071203",
                "name": "WASH complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF10152": "Subunit CCDC53 of WASH complex"
            },
            "panther": {
                "PTHR13015": "PROTEIN AD-016-RELATED"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR019309",
            "name": "WASH complex subunit 3",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "WASH complex subunit 3",
            "short": "WASHC3"
        },
        "description": [
            {
                "text": "<p>The WASH (WASP and Scar homologue) complex is present at the surface of endosomes and recruits and activates the Arp2/3 complex to induce mediated actin nucleation. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting [[cite:PUB00054152]].</p>\n\n<p>The WASH complex consists of several subunits: F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 (strumpellin) and CCDC53.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This entry represents the WASH complex subunit 3, also known as CCDC53.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00054152": {
                "PMID": 19922875,
                "ISBN": null,
                "volume": "17",
                "issue": "5",
                "year": 2009,
                "title": "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.",
                "URL": null,
                "raw_pages": "712-23",
                "medline_journal": "Dev Cell",
                "ISO_journal": "Dev. Cell",
                "authors": [
                    "Derivery E",
                    "Sousa C",
                    "Gautier JJ",
                    "Lombard B",
                    "Loew D",
                    "Gautreau A."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.devcel.2009.09.010"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 191,
            "interactions": 0,
            "matches": 5168,
            "pathways": 0,
            "proteins": 3156,
            "proteomes": 1349,
            "sets": 0,
            "structural_models": {
                "alphafold": 2608,
                "bfvd": 1
            },
            "structures": 0,
            "taxa": 4775
        },
        "entry_annotations": {
            "alignment:seed": 49,
            "alignment:full": 2998
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}