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{
    "metadata": {
        "accession": "IPR019155",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF09758": "Uncharacterised conserved protein"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR019155",
            "name": "CLEC16A/TT9, N-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "CLEC16A/TT9, N-terminal",
            "short": "CLEC16A/TT9_N"
        },
        "description": [
            {
                "text": "<p>CLEC16A (C-Type Lectin Domain Containing 16A) has an inhibitory role in autophagy, probably by activating the mTOR pathway [[cite:PUB00088312]]. It also has a role in beta-cells as a regulator of mitophagy [[cite:PUB00088313]].</p>\r\n\r\n<p>GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [[cite:PUB00088314]].</p>\r\n\r\n<p>This entry represents a domain found at the N terminus of CLEC16A and GFS9/TT9.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00088312": {
                "PMID": 28223137,
                "ISBN": null,
                "volume": "352",
                "issue": "2",
                "year": 2017,
                "title": "Human CLEC16A regulates autophagy through modulating mTOR activity.",
                "URL": null,
                "raw_pages": "304-312",
                "medline_journal": "Exp Cell Res",
                "ISO_journal": "Exp. Cell Res.",
                "authors": [
                    "Tam RC",
                    "Li MW",
                    "Gao YP",
                    "Pang YT",
                    "Yan S",
                    "Ge W",
                    "Lau CS",
                    "Chan VS."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.yexcr.2017.02.017"
            },
            "PUB00088313": {
                "PMID": 24949970,
                "ISBN": null,
                "volume": "157",
                "issue": "7",
                "year": 2014,
                "title": "The diabetes susceptibility gene Clec16a regulates mitophagy.",
                "URL": null,
                "raw_pages": "1577-90",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Soleimanpour SA",
                    "Gupta A",
                    "Bakay M",
                    "Ferrari AM",
                    "Groff DN",
                    "Fadista J",
                    "Spruce LA",
                    "Kushner JA",
                    "Groop L",
                    "Seeholzer SH",
                    "Kaufman BA",
                    "Hakonarson H",
                    "Stoffers DA."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.cell.2014.05.016"
            },
            "PUB00088314": {
                "PMID": 25116949,
                "ISBN": null,
                "volume": "80",
                "issue": "3",
                "year": 2014,
                "title": "GFS9/TT9 contributes to intracellular membrane trafficking and flavonoid accumulation in Arabidopsis thaliana.",
                "URL": null,
                "raw_pages": "410-23",
                "medline_journal": "Plant J",
                "ISO_journal": "Plant J.",
                "authors": [
                    "Ichino T",
                    "Fuji K",
                    "Ueda H",
                    "Takahashi H",
                    "Koumoto Y",
                    "Takagi J",
                    "Tamura K",
                    "Sasaki R",
                    "Aoki K",
                    "Shimada T",
                    "Hara-Nishimura I."
                ],
                "DOI_URL": "https://doi.org/10.1111/tpj.12637"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 68,
            "interactions": 0,
            "matches": 4812,
            "pathways": 0,
            "proteins": 4732,
            "proteomes": 1801,
            "sets": 0,
            "structural_models": {
                "alphafold": 3982,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 5917
        },
        "entry_annotations": {
            "alignment:seed": 28,
            "alignment:full": 3104
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}