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{
"metadata": {
"accession": "IPR017475",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"TIGR03025": "exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR017475",
"name": "Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase",
"type": "Family",
"children": [
{
"accession": "IPR017464",
"name": "Sugar transferase, PEP-CTERM system associated",
"type": "Family",
"children": []
},
{
"accession": "IPR017472",
"name": "Undecaprenyl-phosphate galactose phosphotransferase, WbaP",
"type": "Family",
"children": []
},
{
"accession": "IPR017473",
"name": "Undecaprenyl-phosphate glucose phosphotransferase, WcaJ",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase",
"short": "EPS_sugar_tfrase"
},
"description": [
{
"text": "<p>Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain ([interpro:IPR003362]). Characterised and partially characterised members of this subfamily include Salmonella WbaP (originally RfbP) [[cite:PUB00042823]], Escherichia coli WcaJ [[cite:PUB00042825], [cite:PUB00060981]], Methylobacillus EpsB [[cite:PUB00021014]], Xanthomonas GumD [[cite:PUB00042826]], Vibrio CpsA [[cite:PUB00042827]], Erwinia AmsG [[cite:PUB00042828]], Group B Streptococcus CpsE (originally CpsD) [[cite:PUB00042829]], and Streptococcus suis Cps2E [[cite:PUB00042830]]. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide \"block\". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a \"flippase\" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes such as Sinorhizobium ExoY [[cite:PUB00042831]] and Lactococcus EpsD [[cite:PUB00042832]] lack the N-terminal domain and are not identified by this entry.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00042823": {
"PMID": 8626328,
"ISBN": null,
"volume": "178",
"issue": "9",
"year": 1996,
"title": "C-terminal half of Salmonella enterica WbaP (RfbP) is the galactosyl-1-phosphate transferase domain catalyzing the first step of O-antigen synthesis.",
"URL": null,
"raw_pages": "2598-604",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Wang L",
"Liu D",
"Reeves PR."
],
"DOI_URL": "http://jb.asm.org/cgi/content/abstract/178/9/2598"
},
"PUB00042825": {
"PMID": 318640,
"ISBN": null,
"volume": "129",
"issue": "1",
"year": 1977,
"title": "Role of a sugar-lipid intermediate in colanic acid synthesis by Escherichia coli.",
"URL": null,
"raw_pages": "225-36",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Johnson JG",
"Wilson DB."
],
"DOI_URL": "http://jb.asm.org/cgi/content/abstract/129/1/225"
},
"PUB00021014": {
"PMID": 12624205,
"ISBN": null,
"volume": "149",
"issue": "Pt 2",
"year": 2003,
"title": "Genes involved in the synthesis of the exopolysaccharide methanolan by the obligate methylotroph Methylobacillus sp strain 12S.",
"URL": null,
"raw_pages": "431-44",
"medline_journal": "Microbiology",
"ISO_journal": "Microbiology (Reading, Engl.)",
"authors": [
"Yoshida T",
"Ayabe Y",
"Yasunaga M",
"Usami Y",
"Habe H",
"Nojiri H",
"Omori T."
],
"DOI_URL": "http://dx.doi.org/10.1099/mic.0.25913-0"
},
"PUB00042826": {
"PMID": 9537354,
"ISBN": null,
"volume": "180",
"issue": "7",
"year": 1998,
"title": "Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence.",
"URL": null,
"raw_pages": "1607-17",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Katzen F",
"Ferreiro DU",
"Oddo CG",
"Ielmini MV",
"Becker A",
"Puhler A",
"Ielpi L."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=9537354"
},
"PUB00042827": {
"PMID": 12949095,
"ISBN": null,
"volume": "185",
"issue": "18",
"year": 2003,
"title": "Multiple regulators control capsular polysaccharide production in Vibrio parahaemolyticus.",
"URL": null,
"raw_pages": "5431-41",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Guvener ZT",
"McCarter LL."
],
"DOI_URL": "http://dx.doi.org/10.1128/JB.185.18.5431-5441.2003"
},
"PUB00042828": {
"PMID": 7596293,
"ISBN": null,
"volume": "15",
"issue": "5",
"year": 1995,
"title": "Molecular analysis of the ams operon required for exopolysaccharide synthesis of Erwinia amylovora.",
"URL": null,
"raw_pages": "917-33",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol. Microbiol.",
"authors": [
"Bugert P",
"Geider K."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.1995.tb02361.x"
},
"PUB00042829": {
"PMID": 8355611,
"ISBN": null,
"volume": "8",
"issue": "5",
"year": 1993,
"title": "Identification of cpsD, a gene essential for type III capsule expression in group B streptococci.",
"URL": null,
"raw_pages": "843-55",
"medline_journal": "Mol Microbiol",
"ISO_journal": "Mol. Microbiol.",
"authors": [
"Rubens CE",
"Heggen LM",
"Haft RF",
"Wessels MR."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.1993.tb01631.x"
},
"PUB00042830": {
"PMID": 10085014,
"ISBN": null,
"volume": "67",
"issue": "4",
"year": 1999,
"title": "Identification and characterization of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor.",
"URL": null,
"raw_pages": "1750-6",
"medline_journal": "Infect Immun",
"ISO_journal": "Infect. Immun.",
"authors": [
"Smith HE",
"Damman M",
"van der Velde J",
"Wagenaar F",
"Wisselink HJ",
"Stockhofe-Zurwieden N",
"Smits MA."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10085014&action=stream&blobtype=pdf"
},
"PUB00042831": {
"PMID": 14769477,
"ISBN": null,
"volume": "231",
"issue": "1",
"year": 2004,
"title": "The key Sinorhizobium meliloti succinoglycan biosynthesis gene exoY is expressed from two promoters.",
"URL": null,
"raw_pages": "131-6",
"medline_journal": "FEMS Microbiol Lett",
"ISO_journal": "FEMS Microbiol. Lett.",
"authors": [
"Cheng HP",
"Yao SY."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0378-1097(03)00952-2"
},
"PUB00042832": {
"PMID": 10515924,
"ISBN": null,
"volume": "181",
"issue": "20",
"year": 1999,
"title": "Functional analysis of glycosyltransferase genes from Lactococcus lactis and other gram-positive cocci: complementation, expression, and diversity.",
"URL": null,
"raw_pages": "6347-53",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"van Kranenburg R",
"Vos HR",
"van Swam II",
"Kleerebezem M",
"de Vos WM."
],
"DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=10515924&action=stream&blobtype=pdf"
},
"PUB00060981": {
"PMID": 22408159,
"ISBN": null,
"volume": "194",
"issue": "10",
"year": 2012,
"title": "Functional characterization of UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferases of Escherichia coli and Caulobacter crescentus.",
"URL": null,
"raw_pages": "2646-57",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Patel KB",
"Toh E",
"Fernandez XB",
"Hanuszkiewicz A",
"Hardy GG",
"Brun YV",
"Bernards MA",
"Valvano MA."
],
"DOI_URL": "http://dx.doi.org/10.1128/JB.06052-11"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 27509,
"pathways": 0,
"proteins": 27508,
"proteomes": 11422,
"sets": 0,
"structural_models": {
"alphafold": 20779,
"bfvd": 0
},
"structures": 1,
"taxa": 19326
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
