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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR017356",
"entry_id": null,
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{
"identifier": "GO:0005096",
"name": "GTPase activator activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0051056",
"name": "regulation of small GTPase mediated signal transduction",
"category": {
"code": "P",
"name": "biological_process"
}
}
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"accession": "IPR017356",
"name": "Chimaerin",
"type": "Family",
"children": []
},
"name": {
"name": "Chimaerin",
"short": "CHN1/CHN2"
},
"description": [
{
"text": "<p>Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer [[cite:PUB00077022]].</p>",
"llm": false,
"checked": false,
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},
{
"text": "<p>This entry includes alpha-chimaerin (Chn1) and beta-chimaerin (Chn2) from animals.</p>",
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}
],
"wikipedia": null,
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"PUB00032364": {
"PMID": 15507211,
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"volume": "119",
"issue": "3",
"year": 2004,
"title": "Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.",
"URL": null,
"raw_pages": "407-18",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Canagarajah B",
"Leskow FC",
"Ho JY",
"Mischak H",
"Saidi LF",
"Kazanietz MG",
"Hurley JH."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2004.10.012"
},
"PUB00073311": {
"PMID": 17785183,
"ISBN": null,
"volume": "55",
"issue": "5",
"year": 2007,
"title": "alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.",
"URL": null,
"raw_pages": "768-78",
"medline_journal": "Neuron",
"ISO_journal": "Neuron",
"authors": [
"Beg AA",
"Sommer JE",
"Martin JH",
"Scheiffele P."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.neuron.2007.07.036"
},
"PUB00077022": {
"PMID": 23673634,
"ISBN": null,
"volume": "4",
"issue": null,
"year": 2013,
"title": "Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.",
"URL": null,
"raw_pages": "1849",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Gutierrez-Uzquiza A",
"Colon-Gonzalez F",
"Leonard TA",
"Canagarajah BJ",
"Wang H",
"Mayer BJ",
"Hurley JH",
"Kazanietz MG."
],
"DOI_URL": "http://dx.doi.org/10.1038/ncomms2834"
},
"PUB00077023": {
"PMID": 22726444,
"ISBN": null,
"volume": "149",
"issue": "7",
"year": 2012,
"title": "The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.",
"URL": null,
"raw_pages": "1594-606",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Riccomagno MM",
"Hurtado A",
"Wang H",
"Macopson JG",
"Griner EM",
"Betz A",
"Brose N",
"Kazanietz MG",
"Kolodkin AL."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2012.05.018"
}
},
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"matches": 1564,
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"is_llm": false,
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"representative_structure": null
}
}
