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{
    "metadata": {
        "accession": "IPR017251",
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            {
                "identifier": "GO:0097190",
                "name": "apoptotic signaling pathway",
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                "identifier": "GO:0043293",
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                "PIRSF037646": "Apoptotic protease-activating factor 1"
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            "accession": "IPR017251",
            "name": "Apoptotic protease-activating factor 1",
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        "name": {
            "name": "Apoptotic protease-activating factor 1",
            "short": "Apaf-1"
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            {
                "text": "<p>Apoptotic protease activating factor-1 (Apaf-1) is a component protein of the apoptosome [[cite:PUB00072002]]. During apoptosis, cytochrome c is released from mitochondria to the cytosol and binds Apaf-1. Binding of cytochrome c to Apaf-1 allows the recruitment and activation of caspase-9 within the apoptosome [[cite:PUB00043547]].</p>",
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                "volume": "30",
                "issue": "2",
                "year": 2008,
                "title": "PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.",
                "URL": null,
                "raw_pages": "239-47",
                "medline_journal": "Mol Cell",
                "ISO_journal": "Mol. Cell",
                "authors": [
                    "Kim HE",
                    "Jiang X",
                    "Du F",
                    "Wang X."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.molcel.2008.03.014"
            },
            "PUB00072002": {
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                "volume": "5",
                "issue": null,
                "year": 2014,
                "title": "MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis.",
                "URL": null,
                "raw_pages": "e1132",
                "medline_journal": "Cell Death Dis",
                "ISO_journal": "Cell Death Dis",
                "authors": [
                    "Chen Q",
                    "Xu J",
                    "Li L",
                    "Li H",
                    "Mao S",
                    "Zhang F",
                    "Zen K",
                    "Zhang CY",
                    "Zhang Q."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/cddis.2014.92"
            }
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            "taxa": 1847
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        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
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                        "accession": "GenProp2021",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp2021"
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}