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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR017194",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0004674",
"name": "protein serine/threonine kinase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0038023",
"name": "signaling receptor activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0046872",
"name": "metal ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0007178",
"name": "cell surface receptor protein serine/threonine kinase signaling pathway",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0043235",
"name": "receptor complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"pirsf": {
"PIRSF037393": "Transforming growth factor-beta receptor, type II"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000333",
"name": "Ser/Thr protein kinase, TGFB receptor",
"type": "Family",
"children": [
{
"accession": "IPR015771",
"name": "Anti-muellerian hormone receptor, type II",
"type": "Family",
"children": []
},
{
"accession": "IPR017194",
"name": "Transforming growth factor-beta receptor, type II",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Transforming growth factor-beta receptor, type II",
"short": "Transform_growth_fac-b_typ-2"
},
"description": [
{
"text": "<p>This entry represents the transforming growth factor (TGF)-beta receptor type-2, which has serine/threonion kinase activity ([ec:2.7.11.30]) and uses magnesium or manganese as a cofactor. These proteins are the receptors for TGF-beta, a large family of growth and differentiation factors that mobilise complex signalling networks to regulate cellular differentiation, proliferation, motility, adhesion, and apoptosis [[cite:PUB00044617]]. On ligand binding, the type-2 TGF-beta receptor forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type-2 receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00044617": {
"PMID": 18310276,
"ISBN": null,
"volume": "15",
"issue": "1",
"year": 2008,
"title": "Transforming growth factor-beta signaling and ubiquitinators in cancer.",
"URL": null,
"raw_pages": "59-72",
"medline_journal": "Endocr Relat Cancer",
"ISO_journal": "Endocr. Relat. Cancer",
"authors": [
"Glasgow E",
"Mishra L."
],
"DOI_URL": "http://dx.doi.org/10.1677/ERC-07-0168"
},
"PUB00044618": {
"PMID": 9500552,
"ISBN": null,
"volume": "18",
"issue": "3",
"year": 1998,
"title": "Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.",
"URL": null,
"raw_pages": "276-9",
"medline_journal": "Nat Genet",
"ISO_journal": "Nat. Genet.",
"authors": [
"Prolla TA",
"Baker SM",
"Harris AC",
"Tsao JL",
"Yao X",
"Bronner CE",
"Zheng B",
"Gordon M",
"Reneker J",
"Arnheim N",
"Shibata D",
"Bradley A",
"Liskay RM."
],
"DOI_URL": "http://dx.doi.org/10.1038/ng0398-276"
},
"PUB00044619": {
"PMID": 11078757,
"ISBN": null,
"volume": "92",
"issue": "22",
"year": 2000,
"title": "Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma.",
"URL": null,
"raw_pages": "1805-11",
"medline_journal": "J Natl Cancer Inst",
"ISO_journal": "J. Natl. Cancer Inst.",
"authors": [
"Kawakami K",
"Brabender J",
"Lord RV",
"Groshen S",
"Greenwald BD",
"Krasna MJ",
"Yin J",
"Fleisher AS",
"Abraham JM",
"Beer DG",
"Sidransky D",
"Huss HT",
"Demeester TR",
"Eads C",
"Laird PW",
"Ilson DH",
"Kelsen DP",
"Harpole D",
"Moore MB",
"Danenberg KD",
"Danenberg PV",
"Meltzer SJ."
],
"DOI_URL": "http://dx.doi.org/10.1093/jnci/92.22.1805"
},
"PUB00044620": {
"PMID": 15731757,
"ISBN": null,
"volume": "37",
"issue": "3",
"year": 2005,
"title": "A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.",
"URL": null,
"raw_pages": "275-81",
"medline_journal": "Nat Genet",
"ISO_journal": "Nat. Genet.",
"authors": [
"Loeys BL",
"Chen J",
"Neptune ER",
"Judge DP",
"Podowski M",
"Holm T",
"Meyers J",
"Leitch CC",
"Katsanis N",
"Sharifi N",
"Xu FL",
"Myers LA",
"Spevak PJ",
"Cameron DE",
"De Backer J",
"Hellemans J",
"Chen Y",
"Davis EC",
"Webb CL",
"Kress W",
"Coucke P",
"Rifkin DB",
"De Paepe AM",
"Dietz HC."
],
"DOI_URL": "http://dx.doi.org/10.1038/ng1511"
},
"PUB00044621": {
"PMID": 16791849,
"ISBN": null,
"volume": "27",
"issue": "8",
"year": 2006,
"title": "Identification and in silico analyses of novel TGFBR1 and TGFBR2 mutations in Marfan syndrome-related disorders.",
"URL": null,
"raw_pages": "760-9",
"medline_journal": "Hum Mutat",
"ISO_journal": "Hum. Mutat.",
"authors": [
"Matyas G",
"Arnold E",
"Carrel T",
"Baumgartner D",
"Boileau C",
"Berger W",
"Steinmann B."
],
"DOI_URL": "http://dx.doi.org/10.1002/humu.20353"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR011009",
"name": "Protein kinase-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 2136,
"pathways": 22,
"proteins": 2136,
"proteomes": 846,
"sets": 0,
"structural_models": {
"alphafold": 1986,
"bfvd": 0
},
"structures": 0,
"taxa": 3015
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.11.30",
"url": "https://enzyme.expasy.org/EC/2.7.11.30"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
