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{
"metadata": {
"accession": "IPR014716",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cathgene3d": {
"G3DSA:3.90.215.10": "Gamma Fibrinogen, chain A, domain 1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR014716",
"name": "Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1",
"short": "Fibrinogen_a/b/g_C_1"
},
"description": [
{
"text": "<p>Fibrinogen plays key roles in both blood clotting and platelet aggregation. During blood clot formation, the conversion of soluble fibrinogen to insoluble fibrin is triggered by thrombin, resulting in the polymerisation of fibrin, which forms a soft clot; this is then converted to a hard clot by factor XIIIA, which cross-links fibrin molecules. Platelet aggregation involves the binding of the platelet protein receptor integrin α(IIb)-β(3) to the C-terminal D domain of fibrinogen [[cite:PUB00016231]]. In addition to platelet aggregation, platelet-fibrinogen interaction mediates both adhesion and fibrin clot retraction.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This superfamily represents a subdomain of the C-terminal globular D domain found in fibrinogen alpha, beta and gamma chains, and related domains found in protein involved in protein or cell binding.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00017188": {
"PMID": 15837518,
"ISBN": null,
"volume": "70",
"issue": null,
"year": 2005,
"title": "Fibrinogen and fibrin.",
"URL": null,
"raw_pages": "247-99",
"medline_journal": "Adv Protein Chem",
"ISO_journal": "Adv. Protein Chem.",
"authors": [
"Weisel JW."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0065-3233(05)70008-5"
},
"PUB00016233": {
"PMID": 11593005,
"ISBN": null,
"volume": "98",
"issue": "21",
"year": 2001,
"title": "Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution.",
"URL": null,
"raw_pages": "11967-72",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Madrazo J",
"Brown JH",
"Litvinovich S",
"Dominguez R",
"Yakovlev S",
"Medved L",
"Cohen C."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.211439798"
},
"PUB00016231": {
"PMID": 12799374,
"ISBN": null,
"volume": "278",
"issue": "34",
"year": 2003,
"title": "Identification of a novel binding site for platelet integrins alpha IIb beta 3 (GPIIbIIIa) and alpha 5 beta 1 in the gamma C-domain of fibrinogen.",
"URL": null,
"raw_pages": "32251-8",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Podolnikova NP",
"Yakubenko VP",
"Volkov GL",
"Plow EF",
"Ugarova TP."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M300410200"
},
"PUB00016232": {
"PMID": 11460466,
"ISBN": null,
"volume": "936",
"issue": null,
"year": 2001,
"title": "The structure and biological features of fibrinogen and fibrin.",
"URL": null,
"raw_pages": "11-30",
"medline_journal": "Ann N Y Acad Sci",
"ISO_journal": "Ann. N. Y. Acad. Sci.",
"authors": [
"Mosesson MW",
"Siebenlist KR",
"Meh DA."
],
"DOI_URL": "http://www.annalsnyas.org/cgi/content/abstract/936/1/11"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036056",
"name": "Fibrinogen-like, C-terminal",
"type": "homologous_superfamily"
},
{
"accession": "IPR002181",
"name": "Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain",
"type": "domain"
},
{
"accession": "IPR050373",
"name": "Fibrinogen C-terminal domain-containing protein",
"type": "family"
},
{
"accession": "IPR037579",
"name": "Fibrinogen/angiopoietin-like",
"type": "family"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 1,
"matches": 52684,
"pathways": 89,
"proteins": 50545,
"proteomes": 1489,
"sets": 0,
"structural_models": {
"alphafold": 41182,
"bfvd": 2
},
"structures": 121,
"taxa": 5602
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "2jhm",
"name": "Structure of globular heads of M-ficolin at neutral pH"
}
}
}
