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{
    "metadata": {
        "accession": "IPR013627",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF08418": "DNA polymerase alpha subunit B N-terminal"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR013627",
            "name": "DNA polymerase alpha, subunit B, N-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "DNA polymerase alpha, subunit B, N-terminal",
            "short": "Pol_alpha_B_N"
        },
        "description": [
            {
                "text": "<p>This entry represents the N-terminal domain of subunit B of DNA polymerase alpha-primase, an enzyme which is essential for DNA replication in higher eukaryotes as it initiates synthesis on both leading and lagging strand single-stranded DNA templates. It consists of a primase heterodimer that synthesises RNA primers, a DNA polymerase that extends them, and a fourth subunit, p68 (also termed B-subunit), which is believed to regulate the whole complex. This domain docks on the SV40 helicase and activates the viral primosome [[cite:PUB00093651]]. This domain adopts an α-helical fold [[cite:PUB00052915]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00052915": {
                "PMID": 19494830,
                "ISBN": null,
                "volume": "28",
                "issue": "13",
                "year": 2009,
                "title": "3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases.",
                "URL": null,
                "raw_pages": "1978-87",
                "medline_journal": "EMBO J",
                "ISO_journal": "EMBO J.",
                "authors": [
                    "Klinge S",
                    "Nunez-Ramirez R",
                    "Llorca O",
                    "Pellegrini L."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/emboj.2009.150"
            },
            "PUB00093651": {
                "PMID": 20234039,
                "ISBN": null,
                "volume": "285",
                "issue": "22",
                "year": 2010,
                "title": "Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome.",
                "URL": null,
                "raw_pages": "17112-22",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Huang H",
                    "Weiner BE",
                    "Zhang H",
                    "Fuller BE",
                    "Gao Y",
                    "Wile BM",
                    "Zhao K",
                    "Arnett DR",
                    "Chazin WJ",
                    "Fanning E."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR043034",
                "name": "DNA polymerase alpha, subunit B, N-terminal domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 44,
            "interactions": 0,
            "matches": 1849,
            "pathways": 37,
            "proteins": 1849,
            "proteomes": 1103,
            "sets": 0,
            "structural_models": {
                "alphafold": 1656,
                "bfvd": 0
            },
            "structures": 17,
            "taxa": 3945
        },
        "entry_annotations": {
            "alignment:seed": 74,
            "alignment:full": 1115
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}