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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR013604",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0050909",
"name": "sensory perception of taste",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF08395": "7tm Chemosensory receptor"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR013604",
"name": "7TM chemosensory receptor",
"type": "Family",
"children": []
},
"name": {
"name": "7TM chemosensory receptor",
"short": "7TM_chemorcpt"
},
"description": [
{
"text": "<p>This family includes a number of insect chemosensory receptors encoded by gustatory receptor (GR) and odorant receptor (OR) genes across the insect tree of life. They are seven-transmembrane ligand-gated ion channels, showing high sequence divergence, consistent with an ancient origin for the family [[cite:PUB00020866], [cite:PUB00020817], [cite:PUB00152147], [cite:PUB00152149], [cite:PUB00152148]].</p>\n\n<p>This entry also includes some proteins from nematodes such as Egg laying defective protein egl-47 (Probable G-protein coupled receptor egl-47) from Caenorhabditis elegans [[cite:PUB00154497]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00020866": {
"PMID": 14608037,
"ISBN": null,
"volume": "100 Suppl 2",
"issue": null,
"year": 2003,
"title": "Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster.",
"URL": null,
"raw_pages": "14537-42",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Robertson HM",
"Warr CG",
"Carlson JR."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.2335847100"
},
"PUB00020817": {
"PMID": 12364795,
"ISBN": null,
"volume": "298",
"issue": "5591",
"year": 2002,
"title": "G protein-coupled receptors in Anopheles gambiae.",
"URL": null,
"raw_pages": "176-8",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Hill CA",
"Fox AN",
"Pitts RJ",
"Kent LB",
"Tan PL",
"Chrystal MA",
"Cravchik A",
"Collins FH",
"Robertson HM",
"Zwiebel LJ."
],
"DOI_URL": "http://dx.doi.org/10.1126/science.1076196"
},
"PUB00152148": {
"PMID": 30111839,
"ISBN": null,
"volume": "560",
"issue": "7719",
"year": 2018,
"title": "Cryo-EM structure of the insect olfactory receptor Orco.",
"URL": null,
"raw_pages": "447-452",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Butterwick JA",
"Del Marmol J",
"Kim KH",
"Kahlson MA",
"Rogow JA",
"Walz T",
"Ruta V."
],
"DOI_URL": "https://doi.org/10.1038/s41586-018-0420-8"
},
"PUB00152147": {
"PMID": 18408712,
"ISBN": null,
"volume": "452",
"issue": "7190",
"year": 2008,
"title": "Insect olfactory receptors are heteromeric ligand-gated ion channels.",
"URL": null,
"raw_pages": "1002-6",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Sato K",
"Pellegrino M",
"Nakagawa T",
"Nakagawa T",
"Vosshall LB",
"Touhara K."
],
"DOI_URL": "https://doi.org/10.1038/nature06850"
},
"PUB00152149": {
"PMID": 21709218,
"ISBN": null,
"volume": "108",
"issue": "28",
"year": 2011,
"title": "Sugar-regulated cation channel formed by an insect gustatory receptor.",
"URL": null,
"raw_pages": "11680-5",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Sato K",
"Tanaka K",
"Touhara K."
],
"DOI_URL": "https://doi.org/10.1073/pnas.1019622108"
},
"PUB00154497": {
"PMID": 15456826,
"ISBN": null,
"volume": "24",
"issue": "39",
"year": 2004,
"title": "Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior.",
"URL": null,
"raw_pages": "8522-30",
"medline_journal": "J Neurosci",
"ISO_journal": "J Neurosci",
"authors": [
"Moresco JJ",
"Koelle MR."
],
"DOI_URL": "https://doi.org/10.1523/JNEUROSCI.1915-04.2004"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 175,
"interactions": 0,
"matches": 13193,
"pathways": 0,
"proteins": 12305,
"proteomes": 390,
"sets": 0,
"structural_models": {
"alphafold": 11084,
"bfvd": 0
},
"structures": 12,
"taxa": 1775
},
"entry_annotations": {
"alignment:seed": 75,
"alignment:full": 7438
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
