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{
    "metadata": {
        "accession": "IPR012884",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006310",
                "name": "DNA recombination",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF07825": "Excisionase-like protein"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR012884",
            "name": "Excisionase-like",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Excisionase-like",
            "short": "Excisionase-like"
        },
        "description": [
            {
                "text": "<p>The phage-encoded excisionase protein (Xis, [swissprot:P03699]) is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual winged-helix structure in which two α helices are packed against two extended strands. Also present in the structure is a two-stranded anti-parallel β-sheet, whose strands are connected by a four-residue wing. During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of Xis is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal α helix may fold upon interaction with Int and/or DNA [[cite:PUB00016583]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00016583": {
                "PMID": 12460578,
                "ISBN": null,
                "volume": "324",
                "issue": "4",
                "year": 2002,
                "title": "Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein.",
                "URL": null,
                "raw_pages": "791-805",
                "medline_journal": "J Mol Biol",
                "ISO_journal": "J. Mol. Biol.",
                "authors": [
                    "Sam MD",
                    "Papagiannis CV",
                    "Connolly KM",
                    "Corselli L",
                    "Iwahara J",
                    "Lee J",
                    "Phillips M",
                    "Wojciak JM",
                    "Johnson RC",
                    "Clubb RT."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0022-2836(02)01150-6"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR038137",
                "name": "Excisionase-like superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR009061",
                "name": "Putative DNA-binding domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 4,
            "interactions": 0,
            "matches": 1059,
            "pathways": 0,
            "proteins": 1059,
            "proteomes": 281,
            "sets": 0,
            "structural_models": {
                "alphafold": 883,
                "bfvd": 0
            },
            "structures": 9,
            "taxa": 926
        },
        "entry_annotations": {
            "alignment:seed": 2,
            "alignment:full": 111
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "2og0",
            "name": "Crystal Structure of the Lambda Xis-DNA complex"
        }
    }
}