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{
    "metadata": {
        "accession": "IPR012781",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0009750",
                "name": "response to fructose",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "ncbifam": {
                "TIGR02417": "D-fructose-responsive transcription factor"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR012781",
            "name": "D-fructose-responsive transcription factor",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "D-fructose-responsive transcription factor",
            "short": "Fruct_sucro_rep"
        },
        "description": [
            {
                "text": "<p>Members of this family belong the lacI helix-turn-helix family of DNA-binding transcriptional regulators. All members are from the proteobacteria. This entry includes sucrose operon repressor from Klebsiella pneumoniae and catabolite repressor/activator Cra from E. coli. Cra, also known as FruR, is a global transcription factor with both repression and activation activities, controls a large number of the genes for glycolysis and gluconeogenesis [[cite:PUB00092528], [cite:PUB00099577], [cite:PUB00099576]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00099576": {
                "PMID": 33649152,
                "ISBN": null,
                "volume": "203",
                "issue": "10",
                "year": 2021,
                "title": "Cra and cAMP Receptor Protein Have Opposing Roles in the Regulation of <i>fruB</i> in Vibrio cholerae.",
                "URL": null,
                "raw_pages": null,
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J Bacteriol",
                "authors": [
                    "Beck C",
                    "Perry S",
                    "Stoebel DM",
                    "Liu JM."
                ],
                "DOI_URL": null
            },
            "PUB00099577": {
                "PMID": 33476373,
                "ISBN": null,
                "volume": "49",
                "issue": "3",
                "year": 2021,
                "title": "Vibrio cholerae FruR facilitates binding of RNA polymerase to the fru promoter in the presence of fructose 1-phosphate.",
                "URL": null,
                "raw_pages": "1397-1410",
                "medline_journal": "Nucleic Acids Res",
                "ISO_journal": "Nucleic Acids Res",
                "authors": [
                    "Yoon CK",
                    "Kang D",
                    "Kim MK",
                    "Seok YJ."
                ],
                "DOI_URL": null
            },
            "PUB00092528": {
                "PMID": 16115199,
                "ISBN": null,
                "volume": "10",
                "issue": "9",
                "year": 2005,
                "title": "Systematic search for the Cra-binding promoters using genomic SELEX system.",
                "URL": null,
                "raw_pages": "907-18",
                "medline_journal": "Genes Cells",
                "ISO_journal": "Genes Cells",
                "authors": [
                    "Shimada T",
                    "Fujita N",
                    "Maeda M",
                    "Ishihama A."
                ],
                "DOI_URL": "https://doi.org/10.1111/j.1365-2443.2005.00888.x"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR028082",
                "name": "Periplasmic binding protein-like I",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 2853,
            "pathways": 0,
            "proteins": 2853,
            "proteomes": 1097,
            "sets": 0,
            "structural_models": {
                "alphafold": 2302,
                "bfvd": 0
            },
            "structures": 8,
            "taxa": 2014
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7x7h",
            "name": "Crystal structure of Fructose regulator/Histidine phosphocarrier protein complex from Vibrio cholerae"
        }
    }
}