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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR012710",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0047400",
"name": "phosphonoacetate hydrolase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"TIGR02335": "phosphonoacetate hydrolase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR012710",
"name": "Phosphonoacetate hydrolase",
"type": "Family",
"children": []
},
"name": {
"name": "Phosphonoacetate hydrolase",
"short": "Phosphonoacetate_hydro"
},
"description": [
{
"text": "<p>This family consists of examples of phosphonoacetate hydrolase, an enzyme specific for the cleavage of the C-P bond in phosphonoacetate. Phosphonates are organic compounds with a direct C-P bond that is far less labile than the C-O-P bonds of phosphate attachment sites. Phosphonates may be degraded for phosphorus and energy by broad spectrum C-P lyase encoded by a large operon or by specific enzymes for some of the more common phosphonates in nature. This family represents an enzyme from the latter category. It may be found encoded near genes for phosphonate transport and for other specific phosphonatases [[cite:PUB00015581]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00015581": {
"PMID": 9300819,
"ISBN": null,
"volume": "195",
"issue": "1",
"year": 1997,
"title": "Cloning of the phosphonoacetate hydrolase gene from Pseudomonas fluorescens 23F encoding a new type of carbon-phosphorus bond cleaving enzyme and its expression in Escherichia coli and Pseudomonas putida.",
"URL": null,
"raw_pages": "49-53",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Kulakova AN",
"Kulakov LA",
"Quinn JP."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0378-1119(97)00151-0"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR017850",
"name": "Alkaline-phosphatase-like, core domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1260,
"pathways": 0,
"proteins": 1260,
"proteomes": 757,
"sets": 0,
"structural_models": {
"alphafold": 980,
"bfvd": 0
},
"structures": 6,
"taxa": 1439
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0713",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0713"
}
]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.11.1.2",
"url": "https://enzyme.expasy.org/EC/3.11.1.2"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3szy",
"name": "Crystal Structure of Phosphonoacetate hydrolase from Sinorhizobium meliloti 1021 in APO form"
}
}
}
