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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR011901",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0005829",
"name": "cytosol",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"sfld": {
"SFLDG01204": "Grx2-like.1"
},
"ncbifam": {
"TIGR02182": "glutaredoxin, GrxB family"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR040079",
"name": "Glutathione transferase family",
"type": "Family",
"children": [
{
"accession": "IPR002946",
"name": "Intracellular chloride channel",
"type": "Family",
"children": []
},
{
"accession": "IPR003080",
"name": "Glutathione S-transferase, alpha class",
"type": "Family",
"children": []
},
{
"accession": "IPR003081",
"name": "Glutathione S-transferase, Mu class",
"type": "Family",
"children": []
},
{
"accession": "IPR003082",
"name": "Glutathione S-transferase, Pi class",
"type": "Family",
"children": []
},
{
"accession": "IPR003083",
"name": "S-crystallin",
"type": "Family",
"children": []
},
{
"accession": "IPR005442",
"name": "Glutathione S-transferase, omega-class",
"type": "Family",
"children": []
},
{
"accession": "IPR005955",
"name": "Glutathione S-transferases, class Zeta",
"type": "Family",
"children": []
},
{
"accession": "IPR011901",
"name": "Glutaredoxin-2",
"type": "Family",
"children": []
},
{
"accession": "IPR016639",
"name": "Glutathione S-transferase Omega/GSH",
"type": "Family",
"children": []
},
{
"accession": "IPR017298",
"name": "Transcriptional regulator Ure2",
"type": "Family",
"children": []
},
{
"accession": "IPR017410",
"name": "Mitochondrial outer membrane transport complex protein Metaxin 1/3",
"type": "Family",
"children": []
},
{
"accession": "IPR026928",
"name": "FAX/IsoI-like",
"type": "Family",
"children": []
},
{
"accession": "IPR034334",
"name": "Prostaglandin E synthase 2",
"type": "Family",
"children": []
},
{
"accession": "IPR044627",
"name": "Dehydroascorbate reductases DHAR1/2/3/4",
"type": "Family",
"children": []
},
{
"accession": "IPR044628",
"name": "Elongation factor 1-gamma, plant",
"type": "Family",
"children": []
},
{
"accession": "IPR044629",
"name": "Glutathione S-transferase L1/2/3",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Glutaredoxin-2",
"short": "Grx2"
},
"description": [
{
"text": "<p>This family includes the highly abundant Escherichia coli GrxB (Grx2) glutaredoxin which is notably longer than either GrxA or GrxC [[cite:PUB00080848]]. Unlike the other two E. coli glutaredoxins, Grx2 appears to be unable to reduce ribonucleotide reductase [[cite:PUB00015499]], and may have more to do with resistance to redox stress [[cite:PUB00015500]]. Purified Grx2 exhibits glutathione S-transferase activity indicating that it may have a dual-function as glutaredoxin and glutathione S-transferase [[cite:PUB00081920]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00015499": {
"PMID": 15123823,
"ISBN": null,
"volume": "101",
"issue": "19",
"year": 2004,
"title": "Interactions of glutaredoxins, ribonucleotide reductase, and components of the DNA replication system of Escherichia coli.",
"URL": null,
"raw_pages": "7439-44",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Ortenberg R",
"Gon S",
"Porat A",
"Beckwith J."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.0401965101"
},
"PUB00080848": {
"PMID": 9111025,
"ISBN": null,
"volume": "272",
"issue": "17",
"year": 1997,
"title": "Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli.",
"URL": null,
"raw_pages": "11236-43",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Vlamis-Gardikas A",
"Aslund F",
"Spyrou G",
"Bergman T",
"Holmgren A."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.272.17.11236"
},
"PUB00081920": {
"PMID": 25004967,
"ISBN": null,
"volume": "70",
"issue": "Pt 7",
"year": 2014,
"title": "Structure of Escherichia coli Grx2 in complex with glutathione: a dual-function hybrid of glutaredoxin and glutathione S-transferase.",
"URL": null,
"raw_pages": "1907-13",
"medline_journal": "Acta Crystallogr D Biol Crystallogr",
"ISO_journal": "Acta Crystallogr. D Biol. Crystallogr.",
"authors": [
"Ye J",
"Nadar SV",
"Li J",
"Rosen BP."
],
"DOI_URL": "http://dx.doi.org/10.1107/S1399004714009250"
},
"PUB00015500": {
"PMID": 11741965,
"ISBN": null,
"volume": "277",
"issue": "13",
"year": 2002,
"title": "Characterization of Escherichia coli null mutants for glutaredoxin 2.",
"URL": null,
"raw_pages": "10861-8",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Vlamis-Gardikas A",
"Potamitou A",
"Zarivach R",
"Hochman A",
"Holmgren A."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M111024200"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036282",
"name": "Glutathione S-transferase, C-terminal domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1789,
"pathways": 0,
"proteins": 1789,
"proteomes": 707,
"sets": 0,
"structural_models": {
"alphafold": 1513,
"bfvd": 0
},
"structures": 7,
"taxa": 1601
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "7dkp",
"name": "Crystal structure of E. coli Grx2 in complex with GSH at 1.45 A resolution"
}
}
}
