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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR011649",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0048511",
"name": "rhythmic process",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd02978": "KaiB_like"
},
"smart": {
"SM01248": "KaiB"
},
"pfam": {
"PF07689": "KaiB domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR011649",
"name": "KaiB domain",
"type": "Domain",
"children": []
},
"name": {
"name": "KaiB domain",
"short": "KaiB_domain"
},
"description": [
{
"text": "<p>The cyanobacterial clock proteins KaiA, KaiB and SasA are proposed as regulators of the circadian rhythm in cyanobacteria [[cite:PUB00080800], [cite:PUB00080802]]. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an α-β meander motif and is found to be a dimer [[cite:PUB00031335]]. KaiB was originally discovered from the cyanobacterium Synechococcus as part of the circadian clock gene cluster, kaiABC. KaiB attenuates KaiA-enhanced KaiC autokinase activity by interacting with KaiA-KaiC complexes in a circadian fashion [[cite:PUB00015216], [cite:PUB00080803]]. KaiB is membrane-associated as well as cytosolic. The amount of membrane-associated protein peaks in the evening (at circadian time (CT) 12-16) while the cytosolic form peaks later (at CT 20). The rhythmic localisation of KaiB may function in regulating the formation of Kai complexes. SasA is a sensory histidine kinase which associates with KaiC [[cite:PUB00054600]]. Although it is not an essential oscillator component, it is important in enhancing kaiABC expression and is important in metabolic growth control under day/night cycle conditions. SasA contains an N-terminal sensory domain with a TRX fold which is involved in the SasA-KaiC interaction [[cite:PUB00080801]]. This domain shows high sequence similarity with KaiB [[cite:PUB00080798]]. However, the KaiB structure does not show a classical TRX fold. The N-terminal half of KaiB shares the same β-α-β topology as TRX, but the topology of its C-terminal half diverges.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00031335": {
"PMID": 15313603,
"ISBN": null,
"volume": "342",
"issue": "1",
"year": 2004,
"title": "Structure of the N-terminal domain of the circadian clock-associated histidine kinase SasA.",
"URL": null,
"raw_pages": "9-17",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Vakonakis I",
"Klewer DA",
"Williams SB",
"Golden SS",
"LiWang AC."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2004.07.010"
},
"PUB00054600": {
"PMID": 10786837,
"ISBN": null,
"volume": "101",
"issue": "2",
"year": 2000,
"title": "A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria.",
"URL": null,
"raw_pages": "223-33",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Iwasaki H",
"Williams SB",
"Kitayama Y",
"Ishiura M",
"Golden SS",
"Kondo T."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(00)80832-6"
},
"PUB00080803": {
"PMID": 12727879,
"ISBN": null,
"volume": "22",
"issue": "9",
"year": 2003,
"title": "KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system.",
"URL": null,
"raw_pages": "2127-34",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Kitayama Y",
"Iwasaki H",
"Nishiwaki T",
"Kondo T."
],
"DOI_URL": "http://dx.doi.org/10.1093/emboj/cdg212"
},
"PUB00080798": {
"PMID": 15014139,
"ISBN": null,
"volume": "21",
"issue": "8",
"year": 2004,
"title": "Structure and molecular phylogeny of sasA genes in cyanobacteria: insights into evolution of the prokaryotic circadian system.",
"URL": null,
"raw_pages": "1468-76",
"medline_journal": "Mol Biol Evol",
"ISO_journal": "Mol. Biol. Evol.",
"authors": [
"Dvornyk V",
"Deng HW",
"Nevo E."
],
"DOI_URL": "http://dx.doi.org/10.1093/molbev/msh106"
},
"PUB00015216": {
"PMID": 15071498,
"ISBN": null,
"volume": "23",
"issue": "8",
"year": 2004,
"title": "Anabaena circadian clock proteins KaiA and KaiB reveal a potential common binding site to their partner KaiC.",
"URL": null,
"raw_pages": "1688-98",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Garces RG",
"Wu N",
"Gillon W",
"Pai EF."
],
"DOI_URL": "http://dx.doi.org/10.1038/sj.emboj.7600190"
},
"PUB00080800": {
"PMID": 12441347,
"ISBN": null,
"volume": "278",
"issue": "4",
"year": 2003,
"title": "Circadian formation of clock protein complexes by KaiA, KaiB, KaiC, and SasA in cyanobacteria.",
"URL": null,
"raw_pages": "2388-95",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Kageyama H",
"Kondo T",
"Iwasaki H."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M208899200"
},
"PUB00080801": {
"PMID": 12449424,
"ISBN": null,
"volume": "24",
"issue": "1",
"year": 2002,
"title": "Sequence-specific resonance assignments of the N-terminal, 105-residue KaiC-interacting domain of SasA, a protein necessary for a robust circadian rhythm in Synechococcus elongatus.",
"URL": null,
"raw_pages": "77-8",
"medline_journal": "J Biomol NMR",
"ISO_journal": "J. Biomol. NMR",
"authors": [
"Klewer DA",
"Williams SB",
"Golden SS",
"LiWang AC."
],
"DOI_URL": "http://dx.doi.org/10.1023/A:1020649703380"
},
"PUB00080802": {
"PMID": 12727878,
"ISBN": null,
"volume": "22",
"issue": "9",
"year": 2003,
"title": "Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the kaiBC promoter in regulating KaiC.",
"URL": null,
"raw_pages": "2117-26",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Xu Y",
"Mori T",
"Johnson CH."
],
"DOI_URL": "http://dx.doi.org/10.1093/emboj/cdg168"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036249",
"name": "Thioredoxin-like superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 11,
"interactions": 0,
"matches": 2638,
"pathways": 0,
"proteins": 2637,
"proteomes": 993,
"sets": 0,
"structural_models": {
"alphafold": 1959,
"bfvd": 0
},
"structures": 17,
"taxa": 2408
},
"entry_annotations": {
"alignment:seed": 11,
"alignment:full": 1290
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4kun",
"name": "Crystal structure of Legionella pneumophila Lpp1115 / KaiB"
}
}
}
