General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "IPR010600",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0004867",
                "name": "serine-type endopeptidase inhibitor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030212",
                "name": "hyaluronan metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF06668": "Inter-alpha-trypsin inhibitor heavy chain C-terminus"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR010600",
            "name": "Inter-alpha-trypsin inhibitor heavy chain, C-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Inter-alpha-trypsin inhibitor heavy chain, C-terminal",
            "short": "ITI_HC_C"
        },
        "description": [
            {
                "text": "<p>This entry represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact<i>in vitro</i>and<i>in vivo</i>with hyaluronic acid, which promotes the stability of the extra-cellular matrix. This domain is associated with the VWA domain [interpro:IPR002035].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 67,
            "interactions": 0,
            "matches": 5605,
            "pathways": 10,
            "proteins": 5512,
            "proteomes": 789,
            "sets": 0,
            "structural_models": {
                "alphafold": 5058,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 2586
        },
        "entry_annotations": {
            "alignment:seed": 50,
            "alignment:full": 4228
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}