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InterPro-Version: 107.0
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{
    "metadata": {
        "accession": "IPR010073",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0004642",
                "name": "phosphoribosylformylglycinamidine synthase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006189",
                "name": "'de novo' IMP biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "hamap": {
                "MF_00419": "Phosphoribosylformylglycinamidine synthase [purL]"
            },
            "ncbifam": {
                "TIGR01735": "phosphoribosylformylglycinamidine synthase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR010073",
            "name": "Phosphoribosylformylglycinamidine synthase PurL",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Phosphoribosylformylglycinamidine synthase PurL",
            "short": "PurL_large"
        },
        "description": [
            {
                "text": "<p>This entry represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is known as large PurL and is found mostly in eukaryotes and proteobacteria. In Bacillus subtilis PurL (FGAM synthase II), PurQ (FGAM synthase I) and PurS, of unknown function, perform the equivalent function [[cite:PUB00014926]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00014926": {
                "PMID": 10784038,
                "ISBN": null,
                "volume": "146 ( Pt 4)",
                "issue": null,
                "year": 2000,
                "title": "The yexA gene product is required for phosphoribosylformylglycinamidine synthetase activity in Bacillus subtilis.",
                "URL": null,
                "raw_pages": "807-14",
                "medline_journal": "Microbiology",
                "ISO_journal": "Microbiology (Reading, Engl.)",
                "authors": [
                    "Saxild HH",
                    "Nygaard P."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 12746,
            "pathways": 10,
            "proteins": 12746,
            "proteomes": 7773,
            "sets": 0,
            "structural_models": {
                "alphafold": 2186,
                "bfvd": 0
            },
            "structures": 17,
            "taxa": 15359
        },
        "entry_annotations": {},
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp1689",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1689"
                    },
                    {
                        "accession": "GenProp1628",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1628"
                    },
                    {
                        "accession": "GenProp1284",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1284"
                    },
                    {
                        "accession": "GenProp0110",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0110"
                    }
                ]
            },
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "6.3.5.3",
                        "url": "https://enzyme.expasy.org/EC/6.3.5.3"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "6jta",
            "name": "Crystal Structure of D464A L465A mutant of FGAM Synthetase"
        }
    }
}