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{
    "metadata": {
        "accession": "IPR009125",
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            "pfam": {
                "PF14960": "ATP synthase regulation"
            },
            "panther": {
                "PTHR34038": "ATP SYNTHASE MEMBRANE SUBUNIT DAPIT, MITOCHONDRIAL"
            },
            "prints": {
                "PR01821": "DAPIT"
            }
        },
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        "hierarchy": {
            "accession": "IPR009125",
            "name": "ATP synthase membrane subunit K",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "ATP synthase membrane subunit K",
            "short": "ATPMK"
        },
        "description": [
            {
                "text": "<p>ATP synthase membrane subunit K (ATPMK, also known as DAPIT) is a subunit of mitochondrial ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain [[cite:PUB00089720], [cite:PUB00089719]]. In humans ATP5MD (also known as DAPIT) is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria [[cite:PUB00089719], [cite:PUB00094719]].</p>\n\n<p>Mutations of the ATP5MD gene cause mitochondrial complex V deficiency, nuclear type 6 (MC5DN6), an autosomal recessive mitochondrial disorder characterised by gross motor developmental delay manifesting in the first years of life, and subsequent episodic developmental regression [[cite:PUB00094719]].</p>",
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            "PUB00089719": {
                "PMID": 21345788,
                "ISBN": null,
                "volume": "286",
                "issue": "23",
                "year": 2011,
                "title": "Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria.",
                "URL": null,
                "raw_pages": "20292-6",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Ohsakaya S",
                    "Fujikawa M",
                    "Hisabori T",
                    "Yoshida M."
                ],
                "DOI_URL": "https://doi.org/10.1074/jbc.M110.198523"
            },
            "PUB00089720": {
                "PMID": 26161955,
                "ISBN": null,
                "volume": "10",
                "issue": "7",
                "year": 2015,
                "title": "DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.",
                "URL": null,
                "raw_pages": "e0131990",
                "medline_journal": "PLoS One",
                "ISO_journal": "PLoS ONE",
                "authors": [
                    "Kontro H",
                    "Cannino G",
                    "Rustin P",
                    "Dufour E",
                    "Kainulainen H."
                ],
                "DOI_URL": "https://doi.org/10.1371/journal.pone.0131990"
            },
            "PUB00094719": {
                "PMID": 29917077,
                "ISBN": null,
                "volume": "27",
                "issue": "19",
                "year": 2018,
                "title": "USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis.",
                "URL": null,
                "raw_pages": "3305-3312",
                "medline_journal": "Hum Mol Genet",
                "ISO_journal": "Hum. Mol. Genet.",
                "authors": [
                    "Barca E",
                    "Ganetzky RD",
                    "Potluri P",
                    "Juanola-Falgarona M",
                    "Gai X",
                    "Li D",
                    "Jalas C",
                    "Hirsch Y",
                    "Emmanuele V",
                    "Tadesse S",
                    "Ziosi M",
                    "Akman HO",
                    "Chung WK",
                    "Tanji K",
                    "McCormick EM",
                    "Place E",
                    "Consugar M",
                    "Pierce EA",
                    "Hakonarson H",
                    "Wallace DC",
                    "Hirano M",
                    "Falk MJ."
                ],
                "DOI_URL": null
            }
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        "cross_references": {},
        "is_llm": false,
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        "representative_structure": null
    }
}