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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR008824",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0009378",
"name": "four-way junction helicase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006281",
"name": "DNA repair",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006310",
"name": "DNA recombination",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF05496": "Holliday junction DNA helicase RuvB P-loop domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR003593",
"name": "AAA+ ATPase domain",
"type": "Domain",
"children": [
{
"accession": "IPR003439",
"name": "ABC transporter-like, ATP-binding domain",
"type": "Domain",
"children": [
{
"accession": "IPR015853",
"name": "ABC transporter, ferric cation import, FbpC",
"type": "Domain",
"children": []
},
{
"accession": "IPR015855",
"name": "ABC transporter, maltose/maltodextrin import, MalK-like",
"type": "Domain",
"children": []
},
{
"accession": "IPR015856",
"name": "ABC transporter, CbiO/EcfA subunit",
"type": "Domain",
"children": []
},
{
"accession": "IPR015860",
"name": "ABC transporter, teichoic acids export TagH-like",
"type": "Domain",
"children": []
},
{
"accession": "IPR017879",
"name": "PotA, ATP-binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR017911",
"name": "MacB-like, ATP-binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034001",
"name": "ATP-binding cassette transporter, PDR-like subfamily G, domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR034003",
"name": "ATP-binding cassette transporter, PDR-like subfamily G, domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR041701",
"name": "Methionine import ATP-binding protein MetN, ATP-binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047080",
"name": "ATP-binding cassette sub-family C member 9, ATP-binding cassette domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR047082",
"name": "Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR008824",
"name": "RuvB-like, AAA+ ATPase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034348",
"name": "RLI, domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR045427",
"name": "MoxR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR045735",
"name": "Stage III sporulation protein AA, AAA+ ATPase domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "RuvB-like, AAA+ ATPase domain",
"short": "RuvB-like_N"
},
"description": [
{
"text": "<p>This entry represents the N-terminal domain of RuvB-like proteins. It adotps a Rossman fold (αβα sandwich).</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>The RuvB protein makes up part of the RuvABC resolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein [[cite:PUB00011456]]. RuvB is part of the AAA+ superfamily of ATPases.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>The AAA+ superfamily of ATPases is found in all kingdoms of living organisms where they participate in diverse cellular processes including membrane fusion, proteolysis and DNA replication. Although the terms AAA+ and AAA are often used loosely and interchangeably, the classical AAA family members are distinguished by their possession of the SRH region in the AAA module. Many AAA+ proteins are involved in similar processes to those of AAA proteins (facilitation of protein folding and unfolding, assembly or disassembly of proteins complexes, protein transport and degradation), but others function in replication, recombination, repair and transcription. For a review see [[cite:PUB00057226]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00057226": {
"PMID": 11473577,
"ISBN": null,
"volume": "6",
"issue": "7",
"year": 2001,
"title": "AAA+ superfamily ATPases: common structure--diverse function.",
"URL": null,
"raw_pages": "575-97",
"medline_journal": "Genes Cells",
"ISO_journal": "Genes Cells",
"authors": [
"Ogura T",
"Wilkinson AJ."
],
"DOI_URL": "http://dx.doi.org/10.1046/j.1365-2443.2001.00447.x"
},
"PUB00011456": {
"PMID": 12423347,
"ISBN": null,
"volume": "269",
"issue": "22",
"year": 2002,
"title": "The RuvABC resolvasome.",
"URL": null,
"raw_pages": "5492-501",
"medline_journal": "Eur J Biochem",
"ISO_journal": "Eur. J. Biochem.",
"authors": [
"Dickman MJ",
"Ingleston SM",
"Sedelnikova SE",
"Rafferty JB",
"Lloyd RG",
"Grasby JA",
"Hornby DP."
],
"DOI_URL": "http://dx.doi.org/10.1046/j.1432-1033.2002.03250.x"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR027417",
"name": "P-loop containing nucleoside triphosphate hydrolase",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 58,
"interactions": 0,
"matches": 27452,
"pathways": 1,
"proteins": 27431,
"proteomes": 17245,
"sets": 0,
"structural_models": {
"alphafold": 21383,
"bfvd": 0
},
"structures": 25,
"taxa": 29492
},
"entry_annotations": {
"alignment:seed": 91,
"alignment:full": 9873
},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.6.4.-",
"url": "https://enzyme.expasy.org/EC/3.6.4.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
