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{
    "metadata": {
        "accession": "IPR008640",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0019867",
                "name": "outer membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF05658": "YadA head domain repeat (2 copies)"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR008640",
            "name": "Trimeric autotransporter adhesin YadA-like, head domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Trimeric autotransporter adhesin YadA-like, head domain",
            "short": "Adhesin_Head_dom"
        },
        "description": [
            {
                "text": "<p>This entry represents the head domain of YadA. This domain is composed almost solely of β-sheets making a novel nine coiled left-handed parallel β-roll (LPBR), surrounded by a partly disordered (N)-terminal random coil and a C-terminal neck region, which consists of a random coil and a short helix at the start of the stalk domain  [[cite:PUB00029784]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>The Yersinia adhesin A (YadA) is a trimeric autotransporter adhesin of enteric yersiniae. It consists of three major domains: a head mediating adherence to host cells, a stalk involved in serum resistance, and an anchor that forms a membrane pore and is responsible for the autotransport function [[cite:PUB00095166]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00029784": {
                "PMID": 14765110,
                "ISBN": null,
                "volume": "23",
                "issue": "4",
                "year": 2004,
                "title": "The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll.",
                "URL": null,
                "raw_pages": "701-11",
                "medline_journal": "EMBO J",
                "ISO_journal": "EMBO J.",
                "authors": [
                    "Nummelin H",
                    "Merckel MC",
                    "Leo JC",
                    "Lankinen H",
                    "Skurnik M",
                    "Goldman A."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/sj.emboj.7600100"
            },
            "PUB00095166": {
                "PMID": 17921300,
                "ISBN": null,
                "volume": "189",
                "issue": "24",
                "year": 2007,
                "title": "A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport.",
                "URL": null,
                "raw_pages": "9011-9",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Grosskinsky U",
                    "Schutz M",
                    "Fritz M",
                    "Schmid Y",
                    "Lamparter MC",
                    "Szczesny P",
                    "Lupas AN",
                    "Autenrieth IB",
                    "Linke D."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR011049",
                "name": "Serralysin-like metalloprotease, C-terminal",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 3394,
            "interactions": 0,
            "matches": 75885,
            "pathways": 0,
            "proteins": 9694,
            "proteomes": 1873,
            "sets": 0,
            "structural_models": {
                "alphafold": 5110,
                "bfvd": 16
            },
            "structures": 17,
            "taxa": 4104
        },
        "entry_annotations": {
            "alignment:seed": 248,
            "alignment:full": 19823
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7o23",
            "name": "C-terminal head domain of the trimeric autotransporter adhesin BpaC from Burkholderia pseudomallei fused to a GCN4 anchor"
        }
    }
}