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{
    "metadata": {
        "accession": "IPR008625",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR14047": "P ANTIGEN FAMILY MEMBER 5-RELATED"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR008625",
            "name": "G/X antigen",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "G/X antigen",
            "short": "GAGE_fam"
        },
        "description": [
            {
                "text": "<p>This family consists of several GAGE, PAGE and XAGE proteins. These antigens have been implicated in human cancers [[cite:PUB00011341], [cite:PUB00075605]].</p>\n\n<p>PAGE4 from humans is an intrinsically disordered protein [[cite:PUB00094594]]. It has been shown to protect prostate cancer cells from DNA damage and apoptosis under oxidative stress by modulating MAPK signalling pathway [[cite:PUB00094593]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00011341": {
                "PMID": 11992404,
                "ISBN": null,
                "volume": "99",
                "issue": "3",
                "year": 2002,
                "title": "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma.",
                "URL": null,
                "raw_pages": "361-9",
                "medline_journal": "Int J Cancer",
                "ISO_journal": "Int. J. Cancer",
                "authors": [
                    "Zendman AJ",
                    "Van Kraats AA",
                    "Weidle UH",
                    "Ruiter DJ",
                    "Van Muijen GN."
                ],
                "DOI_URL": "http://dx.doi.org/10.1002/ijc.10371"
            },
            "PUB00075605": {
                "PMID": 10197611,
                "ISBN": null,
                "volume": "59",
                "issue": "7",
                "year": 1999,
                "title": "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.",
                "URL": null,
                "raw_pages": "1445-8",
                "medline_journal": "Cancer Res",
                "ISO_journal": "Cancer Res.",
                "authors": [
                    "Brinkmann U",
                    "Vasmatzis G",
                    "Lee B",
                    "Pastan I."
                ],
                "DOI_URL": null
            },
            "PUB00094594": {
                "PMID": 28289210,
                "ISBN": null,
                "volume": "114",
                "issue": "13",
                "year": 2017,
                "title": "Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.",
                "URL": null,
                "raw_pages": "E2644-E2653",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "Kulkarni P",
                    "Jolly MK",
                    "Jia D",
                    "Mooney SM",
                    "Bhargava A",
                    "Kagohara LT",
                    "Chen Y",
                    "Hao P",
                    "He Y",
                    "Veltri RW",
                    "Grishaev A",
                    "Weninger K",
                    "Levine H",
                    "Orban J."
                ],
                "DOI_URL": null
            },
            "PUB00094593": {
                "PMID": 30658679,
                "ISBN": null,
                "volume": "38",
                "issue": "1",
                "year": 2019,
                "title": "PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway.",
                "URL": null,
                "raw_pages": "24",
                "medline_journal": "J Exp Clin Cancer Res",
                "ISO_journal": "J. Exp. Clin. Cancer Res.",
                "authors": [
                    "Lv C",
                    "Fu S",
                    "Dong Q",
                    "Yu Z",
                    "Zhang G",
                    "Kong C",
                    "Fu C",
                    "Zeng Y."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 713,
            "pathways": 0,
            "proteins": 713,
            "proteomes": 103,
            "sets": 0,
            "structural_models": {
                "alphafold": 620,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 334
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}