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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR008422",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0003677",
"name": "DNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006355",
"name": "regulation of DNA-templated transcription",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF05920": "Homeobox KN domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001356",
"name": "Homeodomain",
"type": "Domain",
"children": [
{
"accession": "IPR008422",
"name": "KN homeodomain",
"type": "Domain",
"children": []
},
{
"accession": "IPR020479",
"name": "Homeodomain, metazoa",
"type": "Domain",
"children": [
{
"accession": "IPR000747",
"name": "Homeodomain engrailed",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR056560",
"name": "Nodulin homeobox, homeobox-like domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR058631",
"name": "Teashirt homolog 1-3-like, homeodomain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "KN homeodomain",
"short": "KN_HD"
},
"description": [
{
"text": "<p>This entry represents a homeodomain (HD) present in transcription factors conserved from fungi to human and plants [[cite:PUB00053798]]. Genes encoding these proteins were first identified as TALE homeobox proteins in eukaryotes, (including KNOX and MEIS genes) [[cite:PUB00053798], [cite:PUB00075494], [cite:PUB00020003]]. They have been classified [[cite:PUB00075495], [cite:PUB00075496], [cite:PUB00075497]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00053798": {
"PMID": 17429685,
"ISBN": null,
"volume": "217",
"issue": "5",
"year": 2007,
"title": "Expression patterns of class I KNOX and YABBY genes in Ruscus aculeatus (Asparagaceae) with implications for phylloclade homology.",
"URL": null,
"raw_pages": "363-72",
"medline_journal": "Dev Genes Evol",
"ISO_journal": "Dev. Genes Evol.",
"authors": [
"Hirayama Y",
"Yamada T",
"Oya Y",
"Ito M",
"Kato M",
"Imaichi R."
],
"DOI_URL": "http://dx.doi.org/10.1007/s00427-007-0149-0"
},
"PUB00075494": {
"PMID": 8537382,
"ISBN": null,
"volume": "270",
"issue": "52",
"year": 1995,
"title": "A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif.",
"URL": null,
"raw_pages": "31178-88",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Bertolino E",
"Reimund B",
"Wildt-Perinic D",
"Clerc RG."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.270.52.31178"
},
"PUB00020003": {
"PMID": 9336443,
"ISBN": null,
"volume": "25",
"issue": "21",
"year": 1997,
"title": "Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.",
"URL": null,
"raw_pages": "4173-80",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Burglin TR."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/25.21.4173"
},
"PUB00075495": {
"PMID": 17665086,
"ISBN": null,
"volume": "65",
"issue": "2",
"year": 2007,
"title": "Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution.",
"URL": null,
"raw_pages": "137-53",
"medline_journal": "J Mol Evol",
"ISO_journal": "J. Mol. Evol.",
"authors": [
"Mukherjee K",
"Burglin TR."
],
"DOI_URL": "http://dx.doi.org/10.1007/s00239-006-0023-0"
},
"PUB00075496": {
"PMID": 19734295,
"ISBN": null,
"volume": "26",
"issue": "12",
"year": 2009,
"title": "A comprehensive classification and evolutionary analysis of plant homeobox genes.",
"URL": null,
"raw_pages": "2775-94",
"medline_journal": "Mol Biol Evol",
"ISO_journal": "Mol. Biol. Evol.",
"authors": [
"Mukherjee K",
"Brocchieri L",
"Burglin TR."
],
"DOI_URL": "http://dx.doi.org/10.1093/molbev/msp201"
},
"PUB00075497": {
"PMID": 21557080,
"ISBN": null,
"volume": "52",
"issue": null,
"year": 2011,
"title": "Homeodomain subtypes and functional diversity.",
"URL": null,
"raw_pages": "95-122",
"medline_journal": "Subcell Biochem",
"ISO_journal": "Subcell. Biochem.",
"authors": [
"Burglin TR."
],
"DOI_URL": "http://dx.doi.org/10.1007/978-90-481-9069-0_5"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR009057",
"name": "Homedomain-like superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 400,
"interactions": 0,
"matches": 50878,
"pathways": 11,
"proteins": 50654,
"proteomes": 3226,
"sets": 0,
"structural_models": {
"alphafold": 45470,
"bfvd": 3
},
"structures": 28,
"taxa": 9865
},
"entry_annotations": {
"alignment:seed": 58,
"alignment:full": 32239
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4xrm",
"name": "homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA"
}
}
}
