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{
"metadata": {
"accession": "IPR008070",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0004497",
"name": "monooxygenase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005506",
"name": "iron ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016712",
"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0020037",
"name": "heme binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"prints": {
"PR01687": "EP450ICYP2E"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001128",
"name": "Cytochrome P450",
"type": "Family",
"children": [
{
"accession": "IPR002397",
"name": "Cytochrome P450, B-class",
"type": "Family",
"children": [
{
"accession": "IPR030904",
"name": "Cytochrome P450, CypX",
"type": "Family",
"children": []
},
{
"accession": "IPR031023",
"name": "L-tryptophan 4-nitrase",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR002399",
"name": "Cytochrome P450, mitochondrial",
"type": "Family",
"children": []
},
{
"accession": "IPR002401",
"name": "Cytochrome P450, E-class, group I",
"type": "Family",
"children": [
{
"accession": "IPR008066",
"name": "Cytochrome P450, E-class, group I, CYP1",
"type": "Family",
"children": []
},
{
"accession": "IPR008067",
"name": "Cytochrome P450, E-class, group I, CYP2A-like",
"type": "Family",
"children": []
},
{
"accession": "IPR008068",
"name": "Cytochrome P450, E-class, group I, CYP2B-like",
"type": "Family",
"children": []
},
{
"accession": "IPR008069",
"name": "Cytochrome P450, E-class, group I, CYP2D-like",
"type": "Family",
"children": []
},
{
"accession": "IPR008070",
"name": "Cytochrome P450, E-class, group I, CYP2E-like",
"type": "Family",
"children": []
},
{
"accession": "IPR008071",
"name": "Cytochrome P450, E-class, group I, CYP2J-like",
"type": "Family",
"children": []
},
{
"accession": "IPR020469",
"name": "Cytochrome P450, CYP2 family",
"type": "Family",
"children": []
},
{
"accession": "IPR039983",
"name": "Cholesterol 24-hydroxylase",
"type": "Family",
"children": []
},
{
"accession": "IPR044225",
"name": "Ent-kaurene oxidase, chloroplastic",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR002402",
"name": "Cytochrome P450, E-class, group II",
"type": "Family",
"children": [
{
"accession": "IPR008072",
"name": "Cytochrome P450, E-class, CYP3A",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR002403",
"name": "Cytochrome P450, E-class, group IV",
"type": "Family",
"children": [
{
"accession": "IPR024204",
"name": "Cytochrome P450, cholesterol 7-alpha-monooxygenase-type",
"type": "Family",
"children": [
{
"accession": "IPR027286",
"name": "Prostacyclin synthase",
"type": "Family",
"children": []
},
{
"accession": "IPR030681",
"name": "Cholesterol 7-alpha-monooxygenase",
"type": "Family",
"children": []
},
{
"accession": "IPR030686",
"name": "Cytochrome P450 8B1",
"type": "Family",
"children": []
}
]
}
]
},
{
"accession": "IPR002949",
"name": "Cytochrome P450, E-class, CYP24A, mitochondrial",
"type": "Family",
"children": []
},
{
"accession": "IPR047146",
"name": "Cytochrome P450, E-class, CYP52, fungi",
"type": "Family",
"children": [
{
"accession": "IPR002974",
"name": "Cytochrome P450, E-class, CYP52, ascomycetes",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR050121",
"name": "Cytochrome P450 monooxygenase",
"type": "Family",
"children": []
},
{
"accession": "IPR050182",
"name": "Cytochrome P450 family 2",
"type": "Family",
"children": []
},
{
"accession": "IPR050364",
"name": "Cytochrome P450 monooxygenase, fungi",
"type": "Family",
"children": []
},
{
"accession": "IPR050479",
"name": "Cytochrome P450, families 11 and 27",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Cytochrome P450, E-class, group I, CYP2E-like",
"short": "Cyt_P450_E_grp-I_CYP2E-like"
},
"description": [
{
"text": "<p>Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea (Streptomyces erythraeus).</p>\r\n<p>Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so a single atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium [[cite:PUB00033966]], which has haem and flavin domains.</p>\r\n<p>Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.</p>\r\n<p>Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) -a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) -NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [[cite:PUB00033965], [cite:PUB00033967], [cite:PUB00033969]]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I). The divergence of the cytochrome P450 superfamily into B-and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the CYP2E family from group I, class E, cytochrome P450 proteins, as well as other CYP2 family proteins. The CYP2 family comprises 15 subfamilies (A-H, J-N, P and Q). The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. These five subfamilies show varied substrate specificities, with some degree of overlap. CYP2E1 metabolises several therapeutic drugs, precarcinogens and solvents to reactive metabolites, and as such is appears involved in cancer susceptibility [[cite:PUB00033979]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00033979": {
"PMID": 9784018,
"ISBN": null,
"volume": "50",
"issue": "4-6",
"year": 1998,
"title": "Impact of CYP2E1 genotype in renal cell and urothelial cancer patients.",
"URL": null,
"raw_pages": "425-31",
"medline_journal": "Exp Toxicol Pathol",
"ISO_journal": "Exp. Toxicol. Pathol.",
"authors": [
"Farker K",
"Lehmann MH",
"Oelschlagel B",
"Haerting J",
"Hoffmann A",
"Janitzky V",
"Schubert J."
],
"DOI_URL": null
},
"PUB00033967": {
"PMID": 15128046,
"ISBN": null,
"volume": "14",
"issue": "1",
"year": 2004,
"title": "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.",
"URL": null,
"raw_pages": "1-18",
"medline_journal": "Pharmacogenetics",
"ISO_journal": "Pharmacogenetics",
"authors": [
"Nelson DR",
"Zeldin DC",
"Hoffman SM",
"Maltais LJ",
"Wain HM",
"Nebert DW."
],
"DOI_URL": "http://dx.doi.org/10.1097/00008571-200401000-00001"
},
"PUB00033966": {
"PMID": 17023115,
"ISBN": null,
"volume": "1770",
"issue": "3",
"year": 2007,
"title": "Cytochrome P450--redox partner fusion enzymes.",
"URL": null,
"raw_pages": "345-59",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Munro AW",
"Girvan HM",
"McLean KJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.bbagen.2006.08.018"
},
"PUB00033965": {
"PMID": 16042601,
"ISBN": null,
"volume": "33",
"issue": "Pt 4",
"year": 2005,
"title": "Biodiversity of cytochrome P450 redox systems.",
"URL": null,
"raw_pages": "796-801",
"medline_journal": "Biochem Soc Trans",
"ISO_journal": "Biochem. Soc. Trans.",
"authors": [
"McLean KJ",
"Sabri M",
"Marshall KR",
"Lawson RJ",
"Lewis DG",
"Clift D",
"Balding PR",
"Dunford AJ",
"Warman AJ",
"McVey JP",
"Quinn AM",
"Sutcliffe MJ",
"Scrutton NS",
"Munro AW."
],
"DOI_URL": "http://www.biochemsoctrans.org/bst/033/0796/bst0330796.htm"
},
"PUB00033969": {
"PMID": 8637843,
"ISBN": null,
"volume": "8",
"issue": "8",
"year": 1995,
"title": "Structural domains of P450-containing monooxygenase systems.",
"URL": null,
"raw_pages": "737-47",
"medline_journal": "Protein Eng",
"ISO_journal": "Protein Eng.",
"authors": [
"Degtyarenko KN."
],
"DOI_URL": "http://dx.doi.org/10.1093/protein/8.8.737"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036396",
"name": "Cytochrome P450 superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1060,
"pathways": 25,
"proteins": 309,
"proteomes": 143,
"sets": 0,
"structural_models": {
"alphafold": 280,
"bfvd": 0
},
"structures": 0,
"taxa": 495
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "1.14.14.1",
"url": "https://enzyme.expasy.org/EC/1.14.14.1"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
