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{
    "metadata": {
        "accession": "IPR007753",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0019028",
                "name": "viral capsid",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd20758": "Cap-0 specific (nucleoside-2'-O-)-methyltransferase of orbivirus"
            },
            "pfam": {
                "PF05059": "Orbivirus VP4 core protein"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR007753",
            "name": "Orbivirus VP4 core",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Orbivirus VP4 core",
            "short": "Orbi_VP4"
        },
        "description": [
            {
                "text": "<p>Orbivirus are double stranded RNA retroviruses of which the Bluetongue virus (BTV) is a member. The core of BTV is a multienzyme complex composed of two major proteins (VP7 and VP3) and three minor proteins (VP1, VP4 and VP6) in addition to the viral genome. VP4 has been shown to perform all RNA capping activities and has both methyltransferase type 1 and type 2 activities associated with it [[cite:PUB00010198], [cite:PUB00041935]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00010198": {
                "PMID": 9811835,
                "ISBN": null,
                "volume": "95",
                "issue": "23",
                "year": 1998,
                "title": "Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus.",
                "URL": null,
                "raw_pages": "13537-42",
                "medline_journal": "Proc Natl Acad Sci U S A",
                "ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
                "authors": [
                    "Ramadevi N",
                    "Burroughs NJ",
                    "Mertens PP",
                    "Jones IM",
                    "Roy P."
                ],
                "DOI_URL": "http://dx.doi.org/10.1073/pnas.95.23.13537"
            },
            "PUB00041935": {
                "PMID": 17417654,
                "ISBN": null,
                "volume": "14",
                "issue": "5",
                "year": 2007,
                "title": "Bluetongue virus VP4 is an RNA-capping assembly line.",
                "URL": null,
                "raw_pages": "449-51",
                "medline_journal": "Nat Struct Mol Biol",
                "ISO_journal": "Nat. Struct. Mol. Biol.",
                "authors": [
                    "Sutton G",
                    "Grimes JM",
                    "Stuart DI",
                    "Roy P."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nsmb1225"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR043026",
                "name": "Orbivirus VP4 core, C-terminal",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 1,
            "interactions": 0,
            "matches": 875,
            "pathways": 0,
            "proteins": 875,
            "proteomes": 20,
            "sets": 0,
            "structural_models": {
                "alphafold": 1,
                "bfvd": 13
            },
            "structures": 5,
            "taxa": 145
        },
        "entry_annotations": {
            "alignment:seed": 26,
            "alignment:full": 32
        },
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp1006",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1006"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}