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{
"metadata": {
"accession": "IPR007714",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF05018": "CFA20 domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR007714",
"name": "CFA20 domain",
"type": "Domain",
"children": []
},
"name": {
"name": "CFA20 domain",
"short": "CFA20_dom"
},
"description": [
{
"text": "<p>This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility [[cite:PUB00072946], [cite:PUB00072975]]. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1 [[cite:PUB00072976], [cite:PUB00072975]].</p>\r\n\r\n<p>Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats [[cite:PUB00072975]]. This domain is also present in the N terminus of uncharacterised protein C3orf67.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00072946": {
"PMID": 20118210,
"ISBN": null,
"volume": "9",
"issue": "4",
"year": 2010,
"title": "Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium.",
"URL": null,
"raw_pages": "645-55",
"medline_journal": "Eukaryot Cell",
"ISO_journal": "Eukaryotic Cell",
"authors": [
"Laligne C",
"Klotz C",
"de Loubresse NG",
"Lemullois M",
"Hori M",
"Laurent FX",
"Papon JF",
"Louis B",
"Cohen J",
"Koll F."
],
"DOI_URL": "http://dx.doi.org/10.1128/EC.00368-09"
},
"PUB00072975": {
"PMID": 24574454,
"ISBN": null,
"volume": "25",
"issue": "9",
"year": 2014,
"title": "FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas.",
"URL": null,
"raw_pages": "1472-83",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol. Biol. Cell",
"authors": [
"Yanagisawa HA",
"Mathis G",
"Oda T",
"Hirono M",
"Richey EA",
"Ishikawa H",
"Marshall WF",
"Kikkawa M",
"Qin H."
],
"DOI_URL": "http://dx.doi.org/10.1091/mbc.E13-08-0464"
},
"PUB00072976": {
"PMID": 24259666,
"ISBN": null,
"volume": "127",
"issue": "Pt 2",
"year": 2014,
"title": "The conserved ciliary protein Bug22 controls planar beating of Chlamydomonas flagella.",
"URL": null,
"raw_pages": "281-7",
"medline_journal": "J Cell Sci",
"ISO_journal": "J. Cell. Sci.",
"authors": [
"Meng D",
"Cao M",
"Oda T",
"Pan J."
],
"DOI_URL": "http://dx.doi.org/10.1242/jcs.140723"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 236,
"interactions": 0,
"matches": 8909,
"pathways": 0,
"proteins": 8476,
"proteomes": 2137,
"sets": 0,
"structural_models": {
"alphafold": 6902,
"bfvd": 0
},
"structures": 26,
"taxa": 8816
},
"entry_annotations": {
"alignment:seed": 29,
"alignment:full": 4963
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
