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{
    "metadata": {
        "accession": "IPR007330",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF04212": "MIT (microtubule interacting and transport) domain"
            },
            "smart": {
                "SM00745": "Microtubule Interacting and Trafficking molecule domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR007330",
            "name": "MIT domain",
            "type": "Domain",
            "children": [
                {
                    "accession": "IPR045253",
                    "name": "Vacuolar protein sorting-associated protein 4, MIT domain",
                    "type": "Domain",
                    "children": []
                },
                {
                    "accession": "IPR045331",
                    "name": "MITD1, N-terminal domain",
                    "type": "Domain",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "MIT domain",
            "short": "MIT_dom"
        },
        "description": [
            {
                "text": "<p>The MIT domain forms an asymmetric three-helix bundle. It is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.</p>\n\n<p>A 'variant' MIT domain has been described at the N-terminal region of a related AAA-ATPase, mammalian katanin p60 represented in [interpro:IPR048611] [[cite:PUB00069769]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00069769": {
                "PMID": 20339000,
                "ISBN": null,
                "volume": "285",
                "issue": "22",
                "year": 2010,
                "title": "A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.",
                "URL": null,
                "raw_pages": "16822-9",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Iwaya N",
                    "Kuwahara Y",
                    "Fujiwara Y",
                    "Goda N",
                    "Tenno T",
                    "Akiyama K",
                    "Mase S",
                    "Tochio H",
                    "Ikegami T",
                    "Shirakawa M",
                    "Hiroaki H."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M110.108365"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036181",
                "name": "MIT domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 323,
            "interactions": 0,
            "matches": 24140,
            "pathways": 26,
            "proteins": 21472,
            "proteomes": 3395,
            "sets": 0,
            "structural_models": {
                "alphafold": 19041,
                "bfvd": 0
            },
            "structures": 36,
            "taxa": 9709
        },
        "entry_annotations": {
            "alignment:seed": 126,
            "alignment:full": 13055
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "5fvk",
            "name": "Crystal structure of Vps4-Vfa1 complex from S.cerevisiae at 1.66 A resolution."
        }
    }
}