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{
    "metadata": {
        "accession": "IPR006942",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0045892",
                "name": "negative regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF04858": "TH1 protein"
            },
            "panther": {
                "PTHR12144": "NEGATIVE ELONGATION FACTOR D"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR006942",
            "name": "TH1 protein",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "TH1 protein",
            "short": "TH1"
        },
        "description": [
            {
                "text": "<p>TH1 is a highly conserved but uncharacterised metazoan protein. No homologue has been identified in Caenorhabditis elegans [[cite:PUB00008673]].  TH1 binds specifically to A-Raf kinase [[cite:PUB00008674]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00008673": {
                "PMID": 11030415,
                "ISBN": null,
                "volume": "107",
                "issue": "2",
                "year": 2000,
                "title": "Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13.",
                "URL": null,
                "raw_pages": "165-75",
                "medline_journal": "Hum Genet",
                "ISO_journal": "Hum. Genet.",
                "authors": [
                    "Bonthron DT",
                    "Hayward BE",
                    "Moran V",
                    "Strain L."
                ],
                "DOI_URL": "http://dx.doi.org/10.1007/s004390000344"
            },
            "PUB00008674": {
                "PMID": 11952167,
                "ISBN": null,
                "volume": "231",
                "issue": "1-2",
                "year": 2002,
                "title": "Identification of TH1 as an interaction partner of A-Raf kinase.",
                "URL": null,
                "raw_pages": "69-74",
                "medline_journal": "Mol Cell Biochem",
                "ISO_journal": "Mol. Cell. Biochem.",
                "authors": [
                    "Yin XL",
                    "Chen S",
                    "Gu JX."
                ],
                "DOI_URL": "http://dx.doi.org/10.1023/A:1014437024129"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 57,
            "interactions": 0,
            "matches": 2852,
            "pathways": 29,
            "proteins": 2664,
            "proteomes": 1522,
            "sets": 0,
            "structural_models": {
                "alphafold": 2385,
                "bfvd": 0
            },
            "structures": 16,
            "taxa": 5057
        },
        "entry_annotations": {
            "alignment:seed": 11,
            "alignment:full": 1918
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}