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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR006252",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd00727": "malate_synt_A"
},
"panther": {
"PTHR42902": "MALATE SYNTHASE"
},
"ncbifam": {
"TIGR01344": "malate synthase A"
},
"pirsf": {
"PIRSF001363": "Malate synthase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR006252",
"name": "Malate synthase A",
"type": "Family",
"children": []
},
"name": {
"name": "Malate synthase A",
"short": "Malate_synthA"
},
"description": [
{
"text": "<p>This entry represents glyoxysomal malate synthases and one of two bacterial forms, designated malate synthase A.</p>\n\n<p>Malate synthase and isocitrate lyase are the two characteristic enzymes of the glyoxylate cycle. The glyoxylate cycle allows certain organisms, like plants and fungi, to derive their carbon requirements from two-carbon compounds, by bypassing the two carboxylation steps of the citric acid cycle [[cite:PUB00080574]]. Isocitrate lyase, first catalyzes the aldol cleavage of isocitrate to succinate (an intermediate of the tricarboxylic acid cycle) and glyoxylate. Then malate synthase catalyzes the condensation of acetyl CoA with glyoxylate to yield malate (another intermediate of the tricarboxylic acid cycle) [[cite:PUB00080575]].</p>\n\n<p>This entry includes [swissprot:A0A0R4IAX5] encoded by ugl gene from zebrafish, which has been recently described as being originated from a duplication of the malate synthase gene, but sequence changes have resulted in loss of malate synthase activity and instead it has ureidoglycolate lyase activity [[cite:PUB00163367]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00080574": {
"PMID": 11252898,
"ISBN": null,
"volume": "1",
"issue": "3",
"year": 2000,
"title": "Krebs and his trinity of cycles.",
"URL": null,
"raw_pages": "225-8",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat. Rev. Mol. Cell Biol.",
"authors": [
"Kornberg H."
],
"DOI_URL": "http://dx.doi.org/10.1038/35043073"
},
"PUB00080575": {
"PMID": 9891796,
"ISBN": null,
"volume": "52",
"issue": null,
"year": 1998,
"title": "Regulation of acetate metabolism by protein phosphorylation in enteric bacteria.",
"URL": null,
"raw_pages": "127-64",
"medline_journal": "Annu Rev Microbiol",
"ISO_journal": "Annu. Rev. Microbiol.",
"authors": [
"Cozzone AJ."
],
"DOI_URL": "http://dx.doi.org/10.1146/annurev.micro.52.1.127"
},
"PUB00163367": {
"PMID": 37043529,
"ISBN": null,
"volume": "120",
"issue": "16",
"year": 2023,
"title": "Identification of hidden associations among eukaryotic genes through statistical analysis of coevolutionary transitions.",
"URL": null,
"raw_pages": "e2218329120",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Dembech E",
"Malatesta M",
"De Rito C",
"Mori G",
"Cavazzini D",
"Secchi A",
"Morandin F",
"Percudani R."
],
"DOI_URL": "https://doi.org/10.1073/pnas.2218329120"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR046363",
"name": "Malate synthase, N-terminal and TIM-barrel domains",
"type": "homologous_superfamily"
},
{
"accession": "IPR011076",
"name": "Malate synthase superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 13845,
"pathways": 4,
"proteins": 13843,
"proteomes": 7855,
"sets": 0,
"structural_models": {
"alphafold": 10714,
"bfvd": 0
},
"structures": 4,
"taxa": 14823
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp1265",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1265"
},
{
"accession": "GenProp1722",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1722"
},
{
"accession": "GenProp0023",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0023"
}
]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.3.3.9",
"url": "https://enzyme.expasy.org/EC/2.3.3.9"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3cuz",
"name": "Atomic Resolution Structures of Escherichia coli and Bacillis anthracis Malate Synthase A: Comparison with Isoform G and Implications for Structure Based Drug Design"
}
}
}
