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{
    "metadata": {
        "accession": "IPR006212",
        "entry_id": null,
        "type": "repeat",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd00064": "FU"
            },
            "smart": {
                "SM00261": "Furin-like repeats"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR006212",
            "name": "Furin-like repeat",
            "type": "Repeat",
            "children": []
        },
        "name": {
            "name": "Furin-like repeat",
            "short": "Furin_repeat"
        },
        "description": [
            {
                "text": "<p>The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation [[cite:PUB00006268], [cite:PUB00093566], [cite:PUB00095139]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00006268": {
                "PMID": 1936959,
                "ISBN": null,
                "volume": "129",
                "issue": "1",
                "year": 1991,
                "title": "Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.",
                "URL": null,
                "raw_pages": "191-201",
                "medline_journal": "Genetics",
                "ISO_journal": "Genetics",
                "authors": [
                    "Raz E",
                    "Schejter ED",
                    "Shilo BZ."
                ],
                "DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1936959"
            },
            "PUB00093566": {
                "PMID": 23756652,
                "ISBN": null,
                "volume": "27",
                "issue": "12",
                "year": 2013,
                "title": "Structural basis for R-spondin recognition by LGR4/5/6 receptors.",
                "URL": null,
                "raw_pages": "1339-44",
                "medline_journal": "Genes Dev",
                "ISO_journal": "Genes Dev.",
                "authors": [
                    "Wang D",
                    "Huang B",
                    "Zhang S",
                    "Yu X",
                    "Wu W",
                    "Wang X."
                ],
                "DOI_URL": null
            },
            "PUB00095139": {
                "PMID": 25480784,
                "ISBN": null,
                "volume": "290",
                "issue": "4",
                "year": 2015,
                "title": "Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).",
                "URL": null,
                "raw_pages": "2455-65",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Xu JG",
                    "Huang C",
                    "Yang Z",
                    "Jin M",
                    "Fu P",
                    "Zhang N",
                    "Luo J",
                    "Li D",
                    "Liu M",
                    "Zhou Y",
                    "Zhu Y."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR009030",
                "name": "Growth factor receptor cysteine-rich domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 146071,
            "pathways": 237,
            "proteins": 39451,
            "proteomes": 1670,
            "sets": 0,
            "structural_models": {
                "alphafold": 24184,
                "bfvd": 3
            },
            "structures": 233,
            "taxa": 5951
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7bhf",
            "name": "DARPin_D5/Her3 domain 4 complex, orthorhombic crystals"
        }
    }
}