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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR006201",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0004888",
"name": "transmembrane signaling receptor activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005216",
"name": "monoatomic ion channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0034220",
"name": "monoatomic ion transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"prints": {
"PR00252": "NRIONCHANNEL"
},
"ncbifam": {
"TIGR00860": "cation transporter family protein"
},
"panther": {
"PTHR18945": "NEUROTRANSMITTER GATED ION CHANNEL"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR006201",
"name": "Neurotransmitter-gated ion-channel",
"type": "Family",
"children": [
{
"accession": "IPR002394",
"name": "Nicotinic acetylcholine receptor",
"type": "Family",
"children": []
},
{
"accession": "IPR006028",
"name": "Gamma-aminobutyric acid A receptor/Glycine receptor alpha",
"type": "Family",
"children": [
{
"accession": "IPR001390",
"name": "Gamma-aminobutyric-acid A receptor, alpha subunit",
"type": "Family",
"children": [
{
"accession": "IPR005431",
"name": "Gamma-aminobutyric-acid A receptor, alpha 1 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005432",
"name": "Gamma-aminobutyric-acid A receptor, alpha 2 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005433",
"name": "Gamma-aminobutyric-acid A receptor, alpha 3 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005434",
"name": "Gamma-aminobutyric-acid A receptor, alpha 4 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005435",
"name": "Gamma-aminobutyric-acid A receptor, alpha 5 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005436",
"name": "Gamma-aminobutyric-acid A receptor, alpha 6 subunit",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR002289",
"name": "Gamma-aminobutyric-acid A receptor, beta subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005437",
"name": "Gamma-aminobutyric acid receptor subunit gamma-1/4",
"type": "Family",
"children": [
{
"accession": "IPR005438",
"name": "Gamma-aminobutyric-acid A receptor, gamma 1 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005439",
"name": "Gamma-aminobutyric-acid A receptor, gamma 2 subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR005440",
"name": "Gamma-aminobutyric-acid A receptor, gamma 3 subunit",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR008057",
"name": "Gamma-aminobutyric-acid A receptor, Rho",
"type": "Family",
"children": [
{
"accession": "IPR008058",
"name": "Gamma-aminobutyric-acid A receptor, Rho1",
"type": "Family",
"children": []
},
{
"accession": "IPR008059",
"name": "Gamma-aminobutyric-acid A receptor, Rho2",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR008098",
"name": "Gamma-aminobutyric-acid A receptor delta subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008099",
"name": "Gamma-aminobutyric-acid A receptor epsilon subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008100",
"name": "Gamma-aminobutyric-acid A receptor pi subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008101",
"name": "Gamma-aminobutyric-acid A receptor theta subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008127",
"name": "Glycine receptor alpha",
"type": "Family",
"children": [
{
"accession": "IPR008128",
"name": "Glycine receptor alpha1",
"type": "Family",
"children": []
},
{
"accession": "IPR008129",
"name": "Glycine receptor alpha2",
"type": "Family",
"children": []
},
{
"accession": "IPR008130",
"name": "Glycine receptor alpha3",
"type": "Family",
"children": []
}
]
}
]
},
{
"accession": "IPR008060",
"name": "Glycine receptor beta",
"type": "Family",
"children": []
},
{
"accession": "IPR008132",
"name": "5-hydroxytryptamine 3 receptor",
"type": "Family",
"children": [
{
"accession": "IPR008133",
"name": "5-hydroxytryptamine 3 receptor, A subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR008134",
"name": "5-hydroxytryptamine 3 receptor, B subunit",
"type": "Family",
"children": []
}
]
}
]
},
"name": {
"name": "Neurotransmitter-gated ion-channel",
"short": "Neur_channel"
},
"description": [
{
"text": "<p>The receptors are composed of varying numbers and types of subunit. Each subunit contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain. The GABA, acetylcholine, serotonin 5HT3 and glycine receptors share a degree of sequence similarity, but differ from the glutamate receptors - sequences of this family possess 2 Cys residues in the N-terminal domain, which, in nicotinic receptors, form a disulphide bond essential for correct folding of the structure [[cite:PUB00087336]].</p>\n\n<p>This entry includes the subunits of the GABA-A, nicotinic, glycine, glutamate and 5HT3 receptors.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [[cite:PUB00002675], [cite:PUB00003455]]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:</p>\r\n\n<ul>\r\n<li>Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [[cite:PUB00044612]].</li>\r\n<li>Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [[cite:PUB00044613]].</li>\r\n<li>Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [[cite:PUB00044614]].</li>\r\n<li>Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [[cite:PUB00010340]].</li>\r\n<li>Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [[cite:PUB00044615]].</li>\r\n</ul>\r\n<p>These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [[cite:PUB00002675], [cite:PUB00003455]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00010340": {
"PMID": 10026168,
"ISBN": null,
"volume": "274",
"issue": "9",
"year": 1999,
"title": "Structural features of the ligand-binding domain of the serotonin 5HT3 receptor.",
"URL": null,
"raw_pages": "5537-41",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Yan D",
"Schulte MK",
"Bloom KE",
"White MM."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.274.9.5537"
},
"PUB00044614": {
"PMID": 18760291,
"ISBN": null,
"volume": null,
"issue": null,
"year": 2008,
"title": "GABA(A) receptors: Subtypes provide diversity of function and pharmacology.",
"URL": null,
"raw_pages": null,
"medline_journal": "Neuropharmacology",
"ISO_journal": "Neuropharmacology",
"authors": [
"Olsen RW",
"Sieghart W."
],
"DOI_URL": null
},
"PUB00044615": {
"PMID": 15165736,
"ISBN": null,
"volume": "27",
"issue": "6",
"year": 2004,
"title": "Structure and gating of the glutamate receptor ion channel.",
"URL": null,
"raw_pages": "321-8",
"medline_journal": "Trends Neurosci",
"ISO_journal": "Trends Neurosci.",
"authors": [
"Wollmuth LP",
"Sobolevsky AI."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.tins.2004.04.005"
},
"PUB00044612": {
"PMID": 18446614,
"ISBN": null,
"volume": "25",
"issue": "4",
"year": 2008,
"title": "Assembly and trafficking of nicotinic acetylcholine receptors (Review).",
"URL": null,
"raw_pages": "279-92",
"medline_journal": "Mol Membr Biol",
"ISO_journal": "Mol. Membr. Biol.",
"authors": [
"Millar NS",
"Harkness PC."
],
"DOI_URL": "http://dx.doi.org/10.1080/09687680802035675"
},
"PUB00002675": {
"PMID": 1721053,
"ISBN": null,
"volume": "266",
"issue": "35",
"year": 1991,
"title": "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.",
"URL": null,
"raw_pages": "23784-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Wagner K",
"Edson K",
"Heginbotham L",
"Post M",
"Huganir RL",
"Czernik AJ."
],
"DOI_URL": "http://intl.jbc.org/cgi/reprint/266/35/23784.pdf"
},
"PUB00003455": {
"PMID": 1846404,
"ISBN": null,
"volume": "56",
"issue": "2",
"year": 1991,
"title": "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.",
"URL": null,
"raw_pages": "713-5",
"medline_journal": "J Neurochem",
"ISO_journal": "J. Neurochem.",
"authors": [
"Kofuji P",
"Wang JB",
"Moss SJ",
"Huganir RL",
"Burt DR."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1471-4159.1991.tb08209.x"
},
"PUB00044613": {
"PMID": 15383648,
"ISBN": null,
"volume": "84",
"issue": "4",
"year": 2004,
"title": "Molecular structure and function of the glycine receptor chloride channel.",
"URL": null,
"raw_pages": "1051-95",
"medline_journal": "Physiol Rev",
"ISO_journal": "Physiol. Rev.",
"authors": [
"Lynch JW."
],
"DOI_URL": null
},
"PUB00087336": {
"PMID": 1356407,
"ISBN": null,
"volume": "3",
"issue": "4",
"year": 1992,
"title": "The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development.",
"URL": null,
"raw_pages": "177-84",
"medline_journal": "J Mol Neurosci",
"ISO_journal": "J. Mol. Neurosci.",
"authors": [
"Wang JB",
"Kofuji P",
"Fernando JC",
"Moss SJ",
"Huganir RL",
"Burt DR."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR038050",
"name": "Neuronal acetylcholine receptor",
"type": "homologous_superfamily"
},
{
"accession": "IPR036719",
"name": "Neurotransmitter-gated ion-channel transmembrane domain superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR036734",
"name": "Neurotransmitter-gated ion-channel ligand-binding domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 96080,
"pathways": 44,
"proteins": 93934,
"proteomes": 1673,
"sets": 0,
"structural_models": {
"alphafold": 86266,
"bfvd": 2
},
"structures": 785,
"taxa": 6055
},
"entry_annotations": {},
"cross_references": {
"prositedoc": {
"displayName": "PROSITE Doc",
"description": "PROSITE is a database of protein families and domains.",
"rank": 18,
"accessions": [
{
"accession": "PDOC00209",
"url": "http://prosite.expasy.org/PDOC00209"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "2qc1",
"name": "Crystal structure of the extracellular domain of the nicotinic acetylcholine receptor 1 subunit bound to alpha-bungarotoxin at 1.9 A resolution"
}
}
}
