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{
"metadata": {
"accession": "IPR006169",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"profile": {
"PS51883": "Obg domain profile"
},
"pfam": {
"PF01018": "GTP1/OBG"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR006169",
"name": "GTP1/OBG domain",
"type": "Domain",
"children": []
},
"name": {
"name": "GTP1/OBG domain",
"short": "GTP1_OBG_dom"
},
"description": [
{
"text": "<p>The N-terminal domain of GTPase Obg has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded β-sandwich. These regions form six left-handed collagen-like helices packed and H-bonded together.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>Several proteins have recently been shown to contain the 5 structural motifs characteristic of GTP-binding proteins [[cite:PUB00000217]]. These include murine DRG protein; GTP1 protein from Schizosaccharomyces pombe; OBG protein from Bacillus subtilis; and several others. Although the proteins contain GTP-binding motifs and are similar to each other, they do not share sequence similarity to other GTP-binding proteins, and have thus been classed as a novel group, the GTP1/OBG family. As yet, the functions of these proteins is uncertain, but they have been shown to be important in development and normal cell metabolism [[cite:PUB00001824], [cite:PUB00002073]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00000217": {
"PMID": 1449490,
"ISBN": null,
"volume": "189",
"issue": "1",
"year": 1992,
"title": "DRG: a novel developmentally regulated GTP-binding protein.",
"URL": null,
"raw_pages": "363-70",
"medline_journal": "Biochem Biophys Res Commun",
"ISO_journal": "Biochem. Biophys. Res. Commun.",
"authors": [
"Sazuka T",
"Tomooka Y",
"Ikawa Y",
"Noda M",
"Kumar S."
],
"DOI_URL": "http://dx.doi.org/10.1016/0006-291X(92)91567-A"
},
"PUB00001824": {
"PMID": 8462872,
"ISBN": null,
"volume": "125",
"issue": "2",
"year": 1993,
"title": "Sequence of the Schizosaccharomyces pombe gtp1 gene and identification of a novel family of putative GTP-binding proteins.",
"URL": null,
"raw_pages": "191-3",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Hudson JD",
"Young PG."
],
"DOI_URL": "http://dx.doi.org/10.1016/0378-1119(93)90327-Y"
},
"PUB00002073": {
"PMID": 2537815,
"ISBN": null,
"volume": "171",
"issue": "3",
"year": 1989,
"title": "The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein.",
"URL": null,
"raw_pages": "1362-71",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Trach K",
"Hoch JA."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=2537815&action=stream&blobtype=pdf"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036726",
"name": "GTP1/OBG domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 180,
"interactions": 0,
"matches": 33734,
"pathways": 0,
"proteins": 33713,
"proteomes": 20475,
"sets": 0,
"structural_models": {
"alphafold": 26990,
"bfvd": 0
},
"structures": 17,
"taxa": 37908
},
"entry_annotations": {
"alignment:seed": 466,
"alignment:full": 15372
},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.6.5.-",
"url": "https://enzyme.expasy.org/EC/3.6.5.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
