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{
"metadata": {
"accession": "IPR005888",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0008460",
"name": "dTDP-glucose 4,6-dehydratase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0009225",
"name": "nucleotide-sugar metabolic process",
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"code": "P",
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}
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"source_database": "interpro",
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"cd05246": "dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs"
},
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"TIGR01181": "dTDP-glucose 4,6-dehydratase"
}
},
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"accession": "IPR005888",
"name": "dTDP-glucose 4,6-dehydratase",
"type": "Family",
"children": []
},
"name": {
"name": "dTDP-glucose 4,6-dehydratase",
"short": "dTDP_Gluc_deHydtase"
},
"description": [
{
"text": "<p>The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia coli dTDP-glucose 4,6-dehydratase takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. The 4,6-dehydratase makes use of tightly bound NAD<sup>+</sup>as the coenzyme for transiently oxidizing the substrate, activating it for the dehydration step [[cite:PUB00007907]]. This and other 4,6-dehydratases catalyze the first committed step in all 6-deoxysugar biosynthetic pathways described to date. Numerous 6-deoxysugars are used in bacterial lipopolysaccharide production as well as in the biosynthesis of a diverse array of secondary metabolites.</p>",
"llm": false,
"checked": false,
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}
],
"wikipedia": null,
"literature": {
"PUB00007907": {
"PMID": 11851427,
"ISBN": null,
"volume": "41",
"issue": "8",
"year": 2002,
"title": "Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase.",
"URL": null,
"raw_pages": "2797-804",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Hegeman AD",
"Gross JW",
"Frey PA."
],
"DOI_URL": "http://dx.doi.org/10.1021/bi011748c"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036291",
"name": "NAD(P)-binding domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
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"domain_architectures": 0,
"interactions": 0,
"matches": 29239,
"pathways": 19,
"proteins": 29233,
"proteomes": 15987,
"sets": 0,
"structural_models": {
"alphafold": 22974,
"bfvd": 1
},
"structures": 16,
"taxa": 29334
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
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"accession": "GenProp1403",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1403"
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{
"accession": "GenProp1713",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1713"
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]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "4.2.1.46",
"url": "https://enzyme.expasy.org/EC/4.2.1.46"
}
]
}
},
"is_llm": false,
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"is_updated_llm": false,
"representative_structure": {
"accession": "1bxk",
"name": "DTDP-GLUCOSE 4,6-DEHYDRATASE FROM E. COLI"
}
}
}
