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{
    "metadata": {
        "accession": "IPR005631",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF03937": "Flavinator of succinate dehydrogenase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR005631",
            "name": "Flavinator of succinate dehydrogenase",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR028882",
                    "name": "Succinate dehydrogenase assembly factor 2, mitochondrial",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "Flavinator of succinate dehydrogenase",
            "short": "SDH"
        },
        "description": [
            {
                "text": "<p>This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE.</p>\r\n\r\n<p>Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans [[cite:PUB00066692]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00066692": {
                "PMID": 19628817,
                "ISBN": null,
                "volume": "325",
                "issue": "5944",
                "year": 2009,
                "title": "SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.",
                "URL": null,
                "raw_pages": "1139-42",
                "medline_journal": "Science",
                "ISO_journal": "Science",
                "authors": [
                    "Hao HX",
                    "Khalimonchuk O",
                    "Schraders M",
                    "Dephoure N",
                    "Bayley JP",
                    "Kunst H",
                    "Devilee P",
                    "Cremers CW",
                    "Schiffman JD",
                    "Bentz BG",
                    "Gygi SP",
                    "Winge DR",
                    "Kremer H",
                    "Rutter J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1126/science.1175689"
            },
            "PUB00066693": {
                "PMID": 22474332,
                "ISBN": null,
                "volume": "287",
                "issue": "22",
                "year": 2012,
                "title": "SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria.",
                "URL": null,
                "raw_pages": "18418-28",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "McNeil MB",
                    "Clulow JS",
                    "Wilf NM",
                    "Salmond GP",
                    "Fineran PC."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.M111.293803"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036714",
                "name": "Flavinator of succinate dehydrogenase superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 78,
            "interactions": 0,
            "matches": 13306,
            "pathways": 10,
            "proteins": 13300,
            "proteomes": 9477,
            "sets": 0,
            "structural_models": {
                "alphafold": 10790,
                "bfvd": 0
            },
            "structures": 9,
            "taxa": 18747
        },
        "entry_annotations": {
            "alignment:seed": 207,
            "alignment:full": 6159
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1x6i",
            "name": "Crystal structure of ygfY from Escherichia coli"
        }
    }
}