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InterPro-Version: 108.0
InterPro-Version-Minor: 0
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{
"metadata": {
"accession": "IPR005256",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0004049",
"name": "anthranilate synthase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0000162",
"name": "L-tryptophan biosynthetic process",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"TIGR00564": "anthranilate synthase component I"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR019999",
"name": "Anthranilate synthase component I-like",
"type": "Family",
"children": [
{
"accession": "IPR005256",
"name": "Anthranilate synthase component I, PabB-like",
"type": "Family",
"children": []
},
{
"accession": "IPR005257",
"name": "Anthranilate synthase component I, TrpE-like, bacterial",
"type": "Family",
"children": []
},
{
"accession": "IPR005802",
"name": "Aminodeoxychorismate synthase, component I",
"type": "Family",
"children": []
},
{
"accession": "IPR010112",
"name": "Anthranilate synthase, bacteria",
"type": "Family",
"children": []
},
{
"accession": "IPR010116",
"name": "Anthranilate synthase component I, archaeal type",
"type": "Family",
"children": []
},
{
"accession": "IPR010118",
"name": "Para-aminobenzoate synthase/anthranilate synthase, component I",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "Anthranilate synthase component I, PabB-like",
"short": "Anth_synth_I_PabB"
},
"description": [
{
"text": "<p>This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes eukaryotes, archaea, and many bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from the other group. The other group includes Gram-negative proteobacteria such as Escherichia coli and Helicobacter pylori but also the Gram-positive organism Corynebacterium glutamicum, and is described by [interpro:IPR005257].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": null,
"set_info": null,
"overlaps_with": [
{
"accession": "IPR005801",
"name": "ADC synthase",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 15585,
"pathways": 2,
"proteins": 15585,
"proteomes": 10717,
"sets": 0,
"structural_models": {
"alphafold": 11997,
"bfvd": 0
},
"structures": 3,
"taxa": 18293
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0037",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0037"
}
]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "4.1.3.27",
"url": "https://enzyme.expasy.org/EC/4.1.3.27"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "7bvd",
"name": "Anthranilate synthase component I (TrpE)[Mycolicibacterium smegmatis]"
}
}
}
