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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR004736",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0022857",
"name": "transmembrane transporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0055085",
"name": "transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"TIGR00883": "metabolite/H+ symporter"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR005828",
"name": "Major facilitator, sugar transporter-like",
"type": "Family",
"children": [
{
"accession": "IPR003663",
"name": "Sugar/inositol transporter",
"type": "Family",
"children": [
{
"accession": "IPR044775",
"name": "Sugar transporter ERD6/Tret1-like",
"type": "Family",
"children": []
},
{
"accession": "IPR045262",
"name": "Sugar transport protein STP/Polyol transporter PLT, plant",
"type": "Family",
"children": [
{
"accession": "IPR044776",
"name": "Polyol transporter 1-6",
"type": "Family",
"children": []
},
{
"accession": "IPR044778",
"name": "Sugar transport protein STP/MST-like, plant",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR045263",
"name": "Glucose transporter GLUT",
"type": "Family",
"children": [
{
"accession": "IPR002439",
"name": "Glucose transporter, type 1 (GLUT1)",
"type": "Family",
"children": []
},
{
"accession": "IPR002440",
"name": "Glucose transporter, type 2 (GLUT2)",
"type": "Family",
"children": []
},
{
"accession": "IPR002441",
"name": "Glucose transporter, type 4 (GLUT4)",
"type": "Family",
"children": []
},
{
"accession": "IPR002442",
"name": "Fructose transporter, type 5 (GLUT5)",
"type": "Family",
"children": []
},
{
"accession": "IPR002945",
"name": "Glucose transporter, type 3 (GLUT3)",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR047984",
"name": "D-xylose-proton symporter-like",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR004736",
"name": "MFS transporter, metabolite:H symporter",
"type": "Family",
"children": []
},
{
"accession": "IPR004738",
"name": "Phosphate permease",
"type": "Family",
"children": []
},
{
"accession": "IPR004749",
"name": "Organic cation transport protein/SVOP",
"type": "Family",
"children": [
{
"accession": "IPR045915",
"name": "Solute carrier family 22 members 4/5",
"type": "Family",
"children": []
}
]
}
]
},
"name": {
"name": "MFS transporter, metabolite:H symporter",
"short": "MHS_symport"
},
"description": [
{
"text": "<p>Recent genome-sequencing data and a wealth of biochemical and molecular genetic investigations have revealed the occurrence of dozens of families of primary and secondary transporters. Two such families have been found to occur ubiquitously in all classifications of living organisms. These are the ATP-binding cassette (ABC) superfamily and the major facilitator superfamily (MFS), also called the uniporter-symporter-antiporter family. While ABC family permeases are in general multicomponent primary active transporters, capable of transporting both small molecules and macromolecules in response to ATP hydrolysis the MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. Although well over 100 families of transporters have now been recognised and classified, the ABC superfamily and MFS account for nearly half of the solute transporters encoded within the genomes of microorganisms. They are also prevalent in higher organisms. The importance of these two families of transport systems to living organisms can therefore not be overestimated [[cite:PUB00007278]].</p>\n\n<p>The MFS was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drug efflux systems, Krebs cycle metabolites, organophosphate:phosphate exchangers, oligosaccharide:H1 symport permeases, and bacterial aromatic acid permeases were all members of the MFS. These observations led to the probability that the MFS is far more widespread in nature and far more diverse in function than had been thought previously. 17 subgroups of the MFS have been identified [[cite:PUB00007278]].</p>\n\n<p>Evidence suggests that the MFS permeases arose by a tandem intragenic duplication event in the early prokaryotes. This event generated a 2-transmembrane-spanner (TMS) protein topology from a primordial 6-TMS unit. Surprisingly, all currently recognised MFS permeases retain the two six-TMS units within a single polypeptide chain, although in 3 of the 17 MFS families, an additional two TMSs are found [[cite:PUB00009720]]. Moreover, the well-conserved MFS specific motif between TMS2 and TMS3 and the related but less well conserved motif between TMS8 and TMS9 [[cite:PUB00009721]] prove to be a characteristic of virtually all of the more than 300 MFS proteins identified.</p>\n\n<p>This entry represents the metabolite-H(+) symport (MHS) subfamily of the MFS. Members include citrate-proton symporters [[cite:PUB00016912]], alpha-ketoglutarate permease [[cite:PUB00033870]], shikimate transporters [[cite:PUB00033871]], glycine betaine/proline/ectoine/pipecolic acid transporter OusA [[cite:PUB00086656]] and the proline/betaine transporter ProP [[cite:PUB00030513]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00016912": {
"PMID": 1718953,
"ISBN": null,
"volume": "110",
"issue": "1",
"year": 1991,
"title": "Cloning and nucleotide sequence of the gene (citA) encoding a citrate carrier from Salmonella typhimurium.",
"URL": null,
"raw_pages": "22-8",
"medline_journal": "J Biochem",
"ISO_journal": "J. Biochem.",
"authors": [
"Shimamoto T",
"Izawa H",
"Daimon H",
"Ishiguro N",
"Shinagawa M",
"Sakano Y",
"Tsuda M",
"Tsuchiya T."
],
"DOI_URL": "http://jb.oxfordjournals.org/cgi/content/abstract/110/1/22"
},
"PUB00033870": {
"PMID": 8419306,
"ISBN": null,
"volume": "175",
"issue": "2",
"year": 1993,
"title": "Membrane topology model of Escherichia coli alpha-ketoglutarate permease by phoA fusion analysis.",
"URL": null,
"raw_pages": "565-7",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Seol W",
"Shatkin AJ."
],
"DOI_URL": "http://jb.asm.org/cgi/content/abstract/175/2/565"
},
"PUB00033871": {
"PMID": 9524262,
"ISBN": null,
"volume": "209",
"issue": "1-2",
"year": 1998,
"title": "Cloning and analysis of the shiA gene, which encodes the shikimate transport system of escherichia coli K-12.",
"URL": null,
"raw_pages": "185-92",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Whipp MJ",
"Camakaris H",
"Pittard AJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0378-1119(98)00043-2"
},
"PUB00030513": {
"PMID": 14643666,
"ISBN": null,
"volume": "334",
"issue": "5",
"year": 2003,
"title": "Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP.",
"URL": null,
"raw_pages": "1063-76",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Zoetewey DL",
"Tripet BP",
"Kutateladze TG",
"Overduin MJ",
"Wood JM",
"Hodges RS."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2003.10.020"
},
"PUB00007278": {
"PMID": 9529885,
"ISBN": null,
"volume": "62",
"issue": "1",
"year": 1998,
"title": "Major facilitator superfamily.",
"URL": null,
"raw_pages": "1-34",
"medline_journal": "Microbiol Mol Biol Rev",
"ISO_journal": "Microbiol. Mol. Biol. Rev.",
"authors": [
"Pao SS",
"Paulsen IT",
"Saier MH Jr."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=9529885"
},
"PUB00009720": {
"PMID": 8987357,
"ISBN": null,
"volume": "60",
"issue": "4",
"year": 1996,
"title": "Proton-dependent multidrug efflux systems.",
"URL": null,
"raw_pages": "575-608",
"medline_journal": "Microbiol Rev",
"ISO_journal": "Microbiol. Rev.",
"authors": [
"Paulsen IT",
"Brown MH",
"Skurray RA."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8987357"
},
"PUB00009721": {
"PMID": 1970645,
"ISBN": null,
"volume": "326",
"issue": "1236",
"year": 1990,
"title": "Homologous sugar transport proteins in Escherichia coli and their relatives in both prokaryotes and eukaryotes.",
"URL": null,
"raw_pages": "391-410",
"medline_journal": "Philos Trans R Soc Lond B Biol Sci",
"ISO_journal": "Philos. Trans. R. Soc. Lond., B, Biol. Sci.",
"authors": [
"Henderson PJ",
"Maiden MC."
],
"DOI_URL": null
},
"PUB00086656": {
"PMID": 16000740,
"ISBN": null,
"volume": "71",
"issue": "7",
"year": 2005,
"title": "OusB, a broad-specificity ABC-type transporter from Erwinia chrysanthemi, mediates uptake of glycine betaine and choline with a high affinity.",
"URL": null,
"raw_pages": "3389-98",
"medline_journal": "Appl Environ Microbiol",
"ISO_journal": "Appl. Environ. Microbiol.",
"authors": [
"Choquet G",
"Jehan N",
"Pissavin C",
"Blanco C",
"Jebbar M."
],
"DOI_URL": "https://doi.org/10.1128/AEM.71.7.3389-3398.2005"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036259",
"name": "MFS transporter superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 9312,
"pathways": 0,
"proteins": 9312,
"proteomes": 2219,
"sets": 0,
"structural_models": {
"alphafold": 7629,
"bfvd": 0
},
"structures": 0,
"taxa": 3768
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
