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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR004656",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0004421",
"name": "hydroxymethylglutaryl-CoA synthase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"hamap": {
"MF_01409": "Hydroxymethylglutaryl-CoA synthase"
},
"ncbifam": {
"TIGR00748": "hydroxymethylglutaryl-CoA synthase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR004656",
"name": "Hydroxymethylglutaryl-CoA synthase",
"type": "Family",
"children": []
},
"name": {
"name": "Hydroxymethylglutaryl-CoA synthase",
"short": "HMG_CoA_Synthase"
},
"description": [
{
"text": "<p>This entry represents Hydroxymethylglutaryl-CoA synthase and related prokaryotic proteins. These proteins show considerable similarity and identical active site residues to FabH, the beta-ketoacyl-acyl carrier protein synthase III of bacteria and plants. They catalyze the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). These enzymes function in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds that are building blocks of archaeal membrane lipids. In Methanocaldococcus jannaschii (Methanococcus jannaschii) [swissprot:Q58941], Cys-112 is the site of acyl group attachment and His-234 and Asn-237 are also active site residues by homology to FabH.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": null,
"set_info": null,
"overlaps_with": [
{
"accession": "IPR016039",
"name": "Thiolase-like",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 656,
"pathways": 6,
"proteins": 656,
"proteomes": 319,
"sets": 0,
"structural_models": {
"alphafold": 628,
"bfvd": 0
},
"structures": 2,
"taxa": 996
},
"entry_annotations": {},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0047",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0047"
}
]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.3.3.10",
"url": "https://enzyme.expasy.org/EC/2.3.3.10"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
