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{
    "metadata": {
        "accession": "IPR004655",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0004315",
                "name": "3-oxoacyl-[acyl-carrier-protein] synthase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006633",
                "name": "fatty acid biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "hamap": {
                "MF_01815": "Beta-ketoacyl-[acyl-carrier-protein] synthase III [fabH]"
            },
            "ncbifam": {
                "TIGR00747": "beta-ketoacyl-ACP synthase III"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR004655",
            "name": "Beta-ketoacyl-[acyl-carrier-protein] synthase III",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Beta-ketoacyl-[acyl-carrier-protein] synthase III",
            "short": "FabH"
        },
        "description": [
            {
                "text": "<p>Beta-ketoacyl-[acyl-carrier-protein] synthase III (FabH) generally initiates elongation in type II fatty acid synthase systems found in bacteria and plants. It is responsible for producing the multitude of fatty acid structures found in bacterial membranes [[cite:PUB00007690]]. The two members of this subfamily from Bacillus subtilis differ from each other, and from FabH from Escherichia coli, in acyl group specificity. Active site residues include Cys112, His244 and Asn274 of Escherichia coli FabH. Cys-112 is the site of acyl group attachment.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00007690": {
                "PMID": 10629181,
                "ISBN": null,
                "volume": "182",
                "issue": "2",
                "year": 2000,
                "title": "beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis.",
                "URL": null,
                "raw_pages": "365-70",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Choi KH",
                    "Heath RJ",
                    "Rock CO."
                ],
                "DOI_URL": "http://dx.doi.org/10.1128/JB.182.2.365-370.2000"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR016039",
                "name": "Thiolase-like",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 28821,
            "pathways": 1,
            "proteins": 28820,
            "proteomes": 15327,
            "sets": 0,
            "structural_models": {
                "alphafold": 21329,
                "bfvd": 0
            },
            "structures": 60,
            "taxa": 26104
        },
        "entry_annotations": {},
        "cross_references": {
            "gp": {
                "displayName": "Genome Properties",
                "description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
                "rank": 45,
                "accessions": [
                    {
                        "accession": "GenProp0681",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0681"
                    },
                    {
                        "accession": "GenProp1512",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1512"
                    },
                    {
                        "accession": "GenProp1220",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1220"
                    },
                    {
                        "accession": "GenProp1415",
                        "url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1415"
                    }
                ]
            },
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "2.3.1",
                        "url": "https://enzyme.expasy.org/EC/2.3.1"
                    },
                    {
                        "accession": "2.3.1.180",
                        "url": "https://enzyme.expasy.org/EC/2.3.1.180"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1hnj",
            "name": "CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + MALONYL-COA"
        }
    }
}