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{
    "metadata": {
        "accession": "IPR004260",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF03013": "Pyrimidine dimer DNA glycosylase"
            },
            "pirsf": {
                "PIRSF001000": "Endonuclease V/pyrimidine dimer DNA glycosylase"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR004260",
            "name": "Pyrimidine dimer DNA glycosylase",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR012650",
                    "name": "Conserved hypothetical protein CHP02328",
                    "type": "Family",
                    "children": []
                },
                {
                    "accession": "IPR021143",
                    "name": "Pyrimidine dimer DNA glycosylase, endonuclease V type",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "Pyrimidine dimer DNA glycosylase",
            "short": "Pyr-dimer_DNA_glycosylase"
        },
        "description": [
            {
                "text": "<p>Pyrimidine dimer DNA glycosylases are enzymes responsible for initiating the base excision repair pathway, excising pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond [[cite:PUB00015082]]. One such enzyme is T4 endonuclease V, an enzyme responsible for the first step of a pyrimidine-dimer-specific excision-repair pathway [[cite:PUB00007456]]. Bacteriophage T4 that are deficient in these enzymes are extremely sensitive to UV.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00007456": {
                "PMID": 2067549,
                "ISBN": null,
                "volume": "255",
                "issue": "1",
                "year": 1991,
                "title": "Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions.",
                "URL": null,
                "raw_pages": "19-29",
                "medline_journal": "Mutat Res",
                "ISO_journal": "Mutat. Res.",
                "authors": [
                    "Dodson ML",
                    "Prince MA",
                    "Anderson WF",
                    "Lloyd RS."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/0921-8777(91)90014-G"
            },
            "PUB00015082": {
                "PMID": 11148051,
                "ISBN": null,
                "volume": "40",
                "issue": "2",
                "year": 2001,
                "title": "The reaction mechanism of DNA glycosylase/AP lyases at abasic sites.",
                "URL": null,
                "raw_pages": "561-8",
                "medline_journal": "Biochemistry",
                "ISO_journal": "Biochemistry",
                "authors": [
                    "McCullough AK",
                    "Sanchez A",
                    "Dodson ML",
                    "Marapaka P",
                    "Taylor JS",
                    "Lloyd RS."
                ],
                "DOI_URL": "http://dx.doi.org/10.1021/bi002404+"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR024796",
                "name": "T4 endonuclease V",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 9,
            "interactions": 0,
            "matches": 4084,
            "pathways": 0,
            "proteins": 4083,
            "proteomes": 2722,
            "sets": 0,
            "structural_models": {
                "alphafold": 2669,
                "bfvd": 8
            },
            "structures": 6,
            "taxa": 5487
        },
        "entry_annotations": {
            "alignment:seed": 72,
            "alignment:full": 1443
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "2end",
            "name": "CRYSTAL STRUCTURE OF A PYRIMIDINE DIMER SPECIFIC EXCISION REPAIR ENZYME FROM BACTERIOPHAGE T4: REFINEMENT AT 1.45 ANGSTROMS AND X-RAY ANALYSIS OF THE THREE ACTIVE SITE MUTANTS"
        }
    }
}