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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR004224",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0006099",
"name": "tricarboxylic acid cycle",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"NF010072": "fumarate reductase cytochrome b subunit"
},
"cdd": {
"cd00581": "QFR_TypeB_TM"
},
"pirsf": {
"PIRSF000177": "Fumarate reductase, cytochrome b subunit"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000701",
"name": "Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit",
"type": "Family",
"children": [
{
"accession": "IPR004224",
"name": "Fumarate reductase type B, transmembrane subunit",
"type": "Family",
"children": []
},
{
"accession": "IPR011138",
"name": "Succinate dehydrogenase cytochrome b558 subunit",
"type": "Family",
"children": [
{
"accession": "IPR016002",
"name": "Succinate dehydrogenase cytochrome b558 subunit, Firmicute",
"type": "Family",
"children": []
}
]
},
{
"accession": "IPR014312",
"name": "Succinate dehydrogenase, hydrophobic membrane anchor",
"type": "Family",
"children": []
},
{
"accession": "IPR014314",
"name": "Succinate dehydrogenase, cytochrome b556 subunit",
"type": "Family",
"children": [
{
"accession": "IPR039023",
"name": "Succinate dehydrogenase membrane subunit SdhC, prokaryotes",
"type": "Family",
"children": []
}
]
}
]
},
"name": {
"name": "Fumarate reductase type B, transmembrane subunit",
"short": "Fum_red_B_TM"
},
"description": [
{
"text": "<p>Quinol:fumarate reductase (QFR) couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone oxidoreductase (SQR). QFR and SQR complexes are collectively referred to as succinate:quinone oxidoreductases and are predicted to share similar structures, containing either 3 or 4 subunits [[cite:PUB00007431]].</p>\r\n\r\n<p>Subunit A (the flavoprotein subunit) contains the site of fumarate reduction and a covalently bound flavin adenine dinucleotide prosthetic group. Subunit B (the iron protein subunit) contains three iron-sulphur centres. Subunit(s) C (and D) (the membrane anchor subunits or cytochrome b subunits) include the membrane-spanning segments and binds haem b molecules [[cite:PUB00007431]]. The composition of these hydrophobic, cytochrome B subunits varies depending on the enzyme subtype.\r\n\r\nType A have two polypeptides, with three transmembrane helices each, and contain two protoheme IX molecules (denoted heme bH and heme bL). Type B have one polypeptide with five transmembrane helices and contain heme bH and heme bL. Type C have the same polypeptide arrangement as Type A, but contains only one protoheme IX molecule, corresponding to heme bH. Type D have two polypeptides, with three transmembrane helices each, and are without heme [[cite:PUB00015792]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00007431": {
"PMID": 10586875,
"ISBN": null,
"volume": "402",
"issue": "6760",
"year": 1999,
"title": "Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution.",
"URL": null,
"raw_pages": "377-85",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Lancaster CR",
"Kroger A",
"Auer M",
"Michel H."
],
"DOI_URL": "http://dx.doi.org/10.1038/46483"
},
"PUB00015792": {
"PMID": 9210286,
"ISBN": null,
"volume": "1320",
"issue": "2",
"year": 1997,
"title": "Succinate: quinone oxidoreductases. Variations on a conserved theme.",
"URL": null,
"raw_pages": "107-41",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Hagerhall C."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0005-2728(97)00019-4"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR034804",
"name": "Fumarate reductase/succinate dehydrogenase, transmembrane subunit",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 721,
"pathways": 0,
"proteins": 721,
"proteomes": 381,
"sets": 0,
"structural_models": {
"alphafold": 592,
"bfvd": 0
},
"structures": 6,
"taxa": 828
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "2bs2",
"name": "QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES"
}
}
}
