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{
    "metadata": {
        "accession": "IPR003567",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0015232",
                "name": "heme transmembrane transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0015886",
                "name": "heme transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0017004",
                "name": "cytochrome complex assembly",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR43653": "CYTOCHROME C ASSEMBLY PROTEIN-RELATED"
            },
            "prints": {
                "PR01410": "CCBIOGENESIS"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR003567",
            "name": "Cytochrome c-type biogenesis protein",
            "type": "Family",
            "children": [
                {
                    "accession": "IPR003568",
                    "name": "Cytochrome c-type biogenesis protein CcmF",
                    "type": "Family",
                    "children": [
                        {
                            "accession": "IPR003570",
                            "name": "Cytochrome c-type biogenesis protein NrfE",
                            "type": "Family",
                            "children": []
                        },
                        {
                            "accession": "IPR017563",
                            "name": "Cytochrome c nitrate reductase biogenesis protein NrfE",
                            "type": "Family",
                            "children": []
                        }
                    ]
                },
                {
                    "accession": "IPR003569",
                    "name": "Probable cytochrome c biosynthesis protein, plants",
                    "type": "Family",
                    "children": []
                }
            ]
        },
        "name": {
            "name": "Cytochrome c-type biogenesis protein",
            "short": "Cyt_c_biogenesis"
        },
        "description": [
            {
                "text": "<p>Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [[cite:PUB00002276]], CcmF [[cite:PUB00002274], [cite:PUB00003599]], NrfE [[cite:PUB00006649]] and CcbS [[cite:PUB00006642]]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase. Members of the family are probably integral membrane proteins, with up to 16 predicted transmembrane (TM) helices.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00002276": {
                "PMID": 7665469,
                "ISBN": null,
                "volume": "177",
                "issue": "17",
                "year": 1995,
                "title": "Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum.",
                "URL": null,
                "raw_pages": "4927-34",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Delgado MJ",
                    "Yeoman KH",
                    "Wu G",
                    "Vargas C",
                    "Davies AE",
                    "Poole RK",
                    "Johnston AW",
                    "Downie JA."
                ],
                "DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=7665469&action=stream&blobtype=pdf"
            },
            "PUB00002274": {
                "PMID": 7635817,
                "ISBN": null,
                "volume": "177",
                "issue": "15",
                "year": 1995,
                "title": "Escherichia coli genes required for cytochrome c maturation.",
                "URL": null,
                "raw_pages": "4321-6",
                "medline_journal": "J Bacteriol",
                "ISO_journal": "J. Bacteriol.",
                "authors": [
                    "Thony-Meyer L",
                    "Fischer F",
                    "Kunzler P",
                    "Ritz D",
                    "Hennecke H."
                ],
                "DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=7635817&action=stream&blobtype=pdf"
            },
            "PUB00003599": {
                "PMID": 9043133,
                "ISBN": null,
                "volume": "143 ( Pt 2)",
                "issue": null,
                "year": 1997,
                "title": "The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter.",
                "URL": null,
                "raw_pages": "563-76",
                "medline_journal": "Microbiology",
                "ISO_journal": "Microbiology (Reading, Engl.)",
                "authors": [
                    "Page MD",
                    "Pearce DA",
                    "Norris HA",
                    "Ferguson SJ."
                ],
                "DOI_URL": null
            },
            "PUB00006649": {
                "PMID": 8057835,
                "ISBN": null,
                "volume": "12",
                "issue": "1",
                "year": 1994,
                "title": "A seven-gene operon essential for formate-dependent nitrite reduction to ammonia by enteric bacteria.",
                "URL": null,
                "raw_pages": "153-63",
                "medline_journal": "Mol Microbiol",
                "ISO_journal": "Mol. Microbiol.",
                "authors": [
                    "Hussain H",
                    "Grove J",
                    "Griffiths L",
                    "Busby S",
                    "Cole J."
                ],
                "DOI_URL": "http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x"
            },
            "PUB00006642": {
                "PMID": 8389979,
                "ISBN": null,
                "volume": "239",
                "issue": "1-2",
                "year": 1993,
                "title": "A plant mitochondrial gene encodes a protein involved in cytochrome c biogenesis.",
                "URL": null,
                "raw_pages": "49-57",
                "medline_journal": "Mol Gen Genet",
                "ISO_journal": "Mol. Gen. Genet.",
                "authors": [
                    "Schuster W",
                    "Combettes B",
                    "Flieger K",
                    "Brennicke A."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 53695,
            "pathways": 0,
            "proteins": 15646,
            "proteomes": 7100,
            "sets": 0,
            "structural_models": {
                "alphafold": 12873,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 14114
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}