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{
"metadata": {
"accession": "IPR003462",
"entry_id": null,
"type": "family",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR13812": "KETIMINE REDUCTASE MU-CRYSTALLIN"
},
"pirsf": {
"PIRSF001439": "Ornithine cyclodeaminase"
},
"pfam": {
"PF02423": "Ornithine cyclodeaminase/mu-crystallin family"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR003462",
"name": "Ornithine cyclodeaminase/mu-crystallin",
"type": "Family",
"children": [
{
"accession": "IPR014334",
"name": "Ectoine utilization protein EutC",
"type": "Family",
"children": []
},
{
"accession": "IPR023866",
"name": "2,3-diaminopropionate biosynthesis protein SbnB",
"type": "Family",
"children": []
},
{
"accession": "IPR028609",
"name": "Alanine dehydrogenase, archaeal-type",
"type": "Family",
"children": [
{
"accession": "IPR012742",
"name": "Alanine dehydrogenase, Archaeoglobus-type",
"type": "Family",
"children": []
}
]
}
]
},
"name": {
"name": "Ornithine cyclodeaminase/mu-crystallin",
"short": "ODC_Mu_crystall"
},
"description": [
{
"text": "<p>This entry represents the ornithine cyclodeaminase-Mu (OCD-MU) family of proteins which are widely distributed and contain proteins with diverse functions [[cite:PUB00163388]]. It includes the bacterial ornithine cyclodeaminase enzyme family, which catalyse the deamination of ornithine to proline [[cite:PUB00009476]]. The family also includes archaeal alanine dehydrogenase [[cite:PUB00017767]] and mu-crystallin, a mammalian homologue of bacterial ornithine cyclodeaminase [[cite:PUB00009477]], which is the major component of the eye lens in several Australian marsupials. mRNA for mu-crystallin has also been found in human retina [[cite:PUB00009477]].</p>\n\n<p>This entry also includes protein SAR DEFICIENT 4 (SARD4) from Arabidopsis. SARD4 is involved in the biosynthesis of pipecolate (Pip), a metabolite that orchestrates defense amplification, positive regulation of salicylic acid (SA) biosynthesis, and priming to guarantee effective local resistance induction and the establishment of systemic acquired resistance (SAR) [[cite:PUB00086414]]. It does not possess ornithine cyclodeaminase activity in vitro [[cite:PUB00086415]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00009476": {
"PMID": 2644238,
"ISBN": null,
"volume": "171",
"issue": "2",
"year": 1989,
"title": "Ornithine cyclodeaminase from octopine Ti plasmid Ach5: identification, DNA sequence, enzyme properties, and comparison with gene and enzyme from nopaline Ti plasmid C58.",
"URL": null,
"raw_pages": "847-54",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Schindler U",
"Sans N",
"Schroder J."
],
"DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=2644238&action=stream&blobtype=pdf"
},
"PUB00009477": {
"PMID": 1384048,
"ISBN": null,
"volume": "89",
"issue": "19",
"year": 1992,
"title": "mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina.",
"URL": null,
"raw_pages": "9292-6",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Kim RY",
"Gasser R",
"Wistow GJ."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1384048"
},
"PUB00017767": {
"PMID": 15516582,
"ISBN": null,
"volume": "186",
"issue": "22",
"year": 2004,
"title": "A novel archaeal alanine dehydrogenase homologous to ornithine cyclodeaminase and mu-crystallin.",
"URL": null,
"raw_pages": "7680-9",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Schroder I",
"Vadas A",
"Johnson E",
"Lim S",
"Monbouquette HG."
],
"DOI_URL": "http://dx.doi.org/10.1128/JB.186.22.7680-7689.2004"
},
"PUB00086414": {
"PMID": 27758894,
"ISBN": null,
"volume": "28",
"issue": "10",
"year": 2016,
"title": "Characterization of a Pipecolic Acid Biosynthesis Pathway Required for Systemic Acquired Resistance.",
"URL": null,
"raw_pages": "2603-2615",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Ding P",
"Rekhter D",
"Ding Y",
"Feussner K",
"Busta L",
"Haroth S",
"Xu S",
"Li X",
"Jetter R",
"Feussner I",
"Zhang Y."
],
"DOI_URL": "https://doi.org/10.1105/tpc.16.00486"
},
"PUB00086415": {
"PMID": 24237637,
"ISBN": null,
"volume": "13",
"issue": null,
"year": 2013,
"title": "Functional characterization of an ornithine cyclodeaminase-like protein of Arabidopsis thaliana.",
"URL": null,
"raw_pages": "182",
"medline_journal": "BMC Plant Biol",
"ISO_journal": "BMC Plant Biol.",
"authors": [
"Sharma S",
"Shinde S",
"Verslues PE."
],
"DOI_URL": "https://doi.org/10.1186/1471-2229-13-182"
},
"PUB00163388": {
"PMID": 34557391,
"ISBN": null,
"volume": "31",
"issue": null,
"year": 2021,
"title": "Imine reduction by an Ornithine cyclodeaminase/μ-crystallin homolog purified from <i>Candida parapsilosis</i> ATCC 7330.",
"URL": null,
"raw_pages": "e00664",
"medline_journal": "Biotechnol Rep (Amst)",
"ISO_journal": "Biotechnol Rep (Amst)",
"authors": [
"Uma Mahesh VNM",
"Chadha A."
],
"DOI_URL": "https://doi.org/10.1016/j.btre.2021.e00664"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036291",
"name": "NAD(P)-binding domain superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR023401",
"name": "Ornithine cyclodeaminase, N-terminal",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 81,
"interactions": 0,
"matches": 27049,
"pathways": 7,
"proteins": 27013,
"proteomes": 10838,
"sets": 0,
"structural_models": {
"alphafold": 20481,
"bfvd": 0
},
"structures": 31,
"taxa": 20455
},
"entry_annotations": {
"alignment:seed": 7,
"alignment:full": 10491
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4mp8",
"name": "Staphyloferrin B precursor biosynthetic enzyme SbnB bound to malonate and NAD+"
}
}
}
