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{
    "metadata": {
        "accession": "IPR003325",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd06974": "Uncharacterized proteins involved in stress response, similar to tellurium resistance terD"
            },
            "pfam": {
                "PF02342": "TerD domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR003325",
            "name": "TerD domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "TerD domain",
            "short": "TerD"
        },
        "description": [
            {
                "text": "<p>The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [[cite:PUB00008105], [cite:PUB00066658]]. It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium binding sites [[cite:PUB00066658], [cite:PUB00054628]] depending on the conservation of aspartates [[cite:PUB00066658]]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways [[cite:PUB00066658]].</p>\n\n<p>TerD domain is also found in cAMP binding protein, chemical-damaging agent resistance proteins and general stress proteins. The cellular Slime mould, Dictyostelium discoideum, contains a cAMP-binding protein, CABP1, which is composed of two subunits. The C-terminal half of these subunits contain this domain [[cite:PUB00008106]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00008105": {
                "PMID": 10203839,
                "ISBN": null,
                "volume": "7",
                "issue": "3",
                "year": 1999,
                "title": "Bacterial tellurite resistance.",
                "URL": null,
                "raw_pages": "111-5",
                "medline_journal": "Trends Microbiol",
                "ISO_journal": "Trends Microbiol.",
                "authors": [
                    "Taylor DE."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0966-842X(99)01454-7"
            },
            "PUB00008106": {
                "PMID": 2176639,
                "ISBN": null,
                "volume": "96",
                "issue": "2",
                "year": 1990,
                "title": "Cloning and characterization of cDNAs encoding a novel cyclic AMP-binding protein in Dictyostelium discoideum.",
                "URL": null,
                "raw_pages": "213-8",
                "medline_journal": "Gene",
                "ISO_journal": "Gene",
                "authors": [
                    "Grant CE",
                    "Tsang A."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/0378-1119(90)90255-P"
            },
            "PUB00066658": {
                "PMID": 23044854,
                "ISBN": null,
                "volume": "8",
                "issue": "12",
                "year": 2012,
                "title": "Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing.",
                "URL": null,
                "raw_pages": "3142-65",
                "medline_journal": "Mol Biosyst",
                "ISO_journal": "Mol Biosyst",
                "authors": [
                    "Anantharaman V",
                    "Iyer LM",
                    "Aravind L."
                ],
                "DOI_URL": "http://dx.doi.org/10.1039/c2mb25239b"
            },
            "PUB00054628": {
                "PMID": 21112337,
                "ISBN": null,
                "volume": "405",
                "issue": "5",
                "year": 2011,
                "title": "NMR Structure and Calcium-Binding Properties of the Tellurite Resistance Protein TerD from Klebsiella pneumoniae.",
                "URL": null,
                "raw_pages": "1188-201",
                "medline_journal": "J Mol Biol",
                "ISO_journal": "J. Mol. Biol.",
                "authors": [
                    "Pan YR",
                    "Lou YC",
                    "Seven AB",
                    "Rizo J",
                    "Chen C."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2010.11.041"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 109,
            "interactions": 0,
            "matches": 31764,
            "pathways": 0,
            "proteins": 28424,
            "proteomes": 3375,
            "sets": 0,
            "structural_models": {
                "alphafold": 18127,
                "bfvd": 1
            },
            "structures": 5,
            "taxa": 6311
        },
        "entry_annotations": {
            "alignment:seed": 166,
            "alignment:full": 10087
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "3ibz",
            "name": "Crystal structure of putative tellurium resistant like protein (TerD) from Streptomyces coelicolor A3(2)"
        }
    }
}