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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR003067",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0009986",
"name": "cell surface",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"prints": {
"PR01303": "CRCMSPRZOITE"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR003067",
"name": "Plasmodium circumsporozoite protein",
"type": "Family",
"children": []
},
"name": {
"name": "Plasmodium circumsporozoite protein",
"short": "Crcmsprzoite"
},
"description": [
{
"text": "<p>The circumsporozoite (CS) protein is the most prominant surface antigen on the sporozoite of the malaria parasite, Plasmodium spp. The sporozoite is the infectious stage of the Plasmodium life cycle, the form in which malaria is passed from the mosquito vector to the mammalian host [[cite:PUB00006466]]. Antibodies to this protein are used in the field to detect exposure to malaria [[cite:PUB00006512]] and it is a target for several vaccines [[cite:PUB00006478]].<p>The sequence of the CS protein consists of head and tail regions, which are largely conserved, and a large set of low-complexity repeats, which are variant across strain and species [[cite:PUB00006235]]. The C-terminal region is probably used for anchoring the protein to the cell membrane, while the central repeat sequences would be the surface antigen of the organism. The repeats, which encode the immunodominant epitope of the CS protein (see [interpro:IPR000884]), diverge more rapidly than the remainder of the gene. It is thought that the maintenance and evolution of the repeats is achieved via a mechanism that acts not at the protein level, but rather directly on the DNA sequence [[cite:PUB00006235]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00006466": {
"PMID": 10639441,
"ISBN": null,
"volume": "68",
"issue": "2",
"year": 2000,
"title": "The cytotoxic T-lymphocyte epitope of the Plasmodium falciparum circumsporozoite protein also modulates the efficiency of receptor-ligand interaction with hepatocytes.",
"URL": null,
"raw_pages": "740-3",
"medline_journal": "Infect Immun",
"ISO_journal": "Infect. Immun.",
"authors": [
"Rathore D",
"McCutchan TF."
],
"DOI_URL": "http://dx.doi.org/10.1128/IAI.68.2.740-743.2000"
},
"PUB00006512": {
"PMID": 10643909,
"ISBN": null,
"volume": "74",
"issue": "1",
"year": 2000,
"title": "Analysis of Plasmodium falciparum infections in a village community in Northern Nigeria: determination of msp2 genotypes and parasite-specific IgG responses.",
"URL": null,
"raw_pages": "63-71",
"medline_journal": "Acta Trop",
"ISO_journal": "Acta Trop.",
"authors": [
"Engelbrecht F",
"Togel E",
"Beck HP",
"Enwezor F",
"Oettli A",
"Felger I."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0001-706X(99)00044-3"
},
"PUB00006478": {
"PMID": 10697892,
"ISBN": null,
"volume": "41",
"issue": "1-3",
"year": 1999,
"title": "Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials.",
"URL": null,
"raw_pages": "397-402",
"medline_journal": "Parassitologia",
"ISO_journal": "Parassitologia",
"authors": [
"Nardin E",
"Zavala F",
"Nussenzweig V",
"Nussenzweig RS."
],
"DOI_URL": null
},
"PUB00006235": {
"PMID": 3802196,
"ISBN": null,
"volume": "48",
"issue": "2",
"year": 1987,
"title": "The circumsporozoite gene of the Plasmodium cynomolgi complex.",
"URL": null,
"raw_pages": "311-9",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Galinski MR",
"Arnot DE",
"Cochrane AH",
"Barnwell JW",
"Nussenzweig RS",
"Enea V."
],
"DOI_URL": "http://dx.doi.org/10.1016/0092-8674(87)90434-X"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036383",
"name": "Thrombospondin type-1 repeat superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 9846,
"pathways": 0,
"proteins": 2365,
"proteomes": 348,
"sets": 0,
"structural_models": {
"alphafold": 2332,
"bfvd": 0
},
"structures": 25,
"taxa": 1105
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "7rxl",
"name": "Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum"
}
}
}
