General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "IPR002772",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0004553",
                "name": "hydrolase activity, hydrolyzing O-glycosyl compounds",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005975",
                "name": "carbohydrate metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF01915": "Glycosyl hydrolase family 3 C-terminal domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR002772",
            "name": "Glycoside hydrolase family 3 C-terminal domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Glycoside hydrolase family 3 C-terminal domain",
            "short": "Glyco_hydro_3_C"
        },
        "description": [
            {
                "text": "<p>Glycoside hydrolase family 3 [cazy:GH3] comprises enzymes with a number of known activities; beta-glucosidase ([ec:3.2.1.21]); beta-xylosidase ([ec:3.2.1.37]); N-acetyl beta-glucosaminidase ([ec:3.2.1.52]); glucan beta-1,3-glucosidase ([ec:3.2.1.58]); cellodextrinase([ec:3.2.1.74]); exo-1,3-1,4-glucanase ([ec:3.2.1]).</p>\r\n\r\n<p>These enzymes are two-domain globular proteins that are N-glycosylated at three sites [[cite:PUB00005846]]. This entry represents the C-terminal domain, involved in catalysis and may be involved in binding beta-glucan [[cite:PUB00005846]]. It is found associated with [pfam:PF00933].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00005846": {
                "PMID": 10368285,
                "ISBN": null,
                "volume": "7",
                "issue": "2",
                "year": 1999,
                "title": "Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase.",
                "URL": null,
                "raw_pages": "179-90",
                "medline_journal": "Structure",
                "ISO_journal": "Structure",
                "authors": [
                    "Varghese JN",
                    "Hrmova M",
                    "Fincher GB."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0969-2126(99)80024-0"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036881",
                "name": "Glycoside hydrolase family 3 C-terminal domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 960,
            "interactions": 0,
            "matches": 79095,
            "pathways": 7,
            "proteins": 78735,
            "proteomes": 11806,
            "sets": 0,
            "structural_models": {
                "alphafold": 61085,
                "bfvd": 0
            },
            "structures": 156,
            "taxa": 21320
        },
        "entry_annotations": {
            "alignment:seed": 116,
            "alignment:full": 36680
        },
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "3.2.1",
                        "url": "https://enzyme.expasy.org/EC/3.2.1"
                    },
                    {
                        "accession": "3.2.1.21",
                        "url": "https://enzyme.expasy.org/EC/3.2.1.21"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}