HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "IPR002455",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0004965",
"name": "G protein-coupled GABA receptor activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0007186",
"name": "G protein-coupled receptor signaling pathway",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"panther": {
"PTHR10519": "GABA-B RECEPTOR"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR002455",
"name": "GPCR family 3, GABA-B receptor",
"type": "Family",
"children": [
{
"accession": "IPR002456",
"name": "GPCR family 3, gamma-aminobutyric acid receptor, type B1",
"type": "Family",
"children": []
},
{
"accession": "IPR002457",
"name": "GPCR family 3, gamma-aminobutyric acid receptor, type B2",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "GPCR family 3, GABA-B receptor",
"short": "GPCR3_GABA-B"
},
"description": [
{
"text": "<p>GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length [[cite:PUB00036049]]. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [[cite:PUB00004309], [cite:PUB00004161], [cite:PUB00036050], [cite:PUB00007343]]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>GABA is the principal inhibitory neurotransmitter in the brain, and signals through ionotropic (type A and type C) and metabotropic (type B) receptor systems. The type B receptors have been cloned, and photoaffinity labelling experiments suggest that they correspond to two highly conserved receptor forms in the vertebrate nervous system [[cite:PUB00005965]]. These receptors are involved in the fine tuning of inhibitory synaptic transmission [[cite:PUB00005966]]. Presynaptic receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, while postsynaptic receptors decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials [[cite:PUB00005966], [cite:PUB00062692]]. The type B receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate. The physiological form of the B receptor is a heterodimer of the B1 and B2 subtypes, in which B1 seems to bind agonists, while B2 mediates coupling to G proteins [[cite:PUB00005967], [cite:PUB00095650], [cite:PUB00095651]].</p>\n\n<p>This entry includes GPR156, a class C orphan GPCR that regulates hair cell orientation, which is important for capturing sound in the cochlea, balancing movements in vestibular organs and sensing water movements in the fish lateral line, and it also plays a role in lipid metabolism [[cite:PUB00155083]]. Unlike GABR1/2, it lacks role the extracellular and exhibits constitutive activity [[cite:PUB00155083]].</p>\n\n<p>Metabotropic glutamate receptor-like proteins (Grl) are similar in structure to GABA-B receptors and belong to the same receptor family [[cite:PUB00076358], [cite:PUB00070398]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00007343": {
"PMID": 9292726,
"ISBN": null,
"volume": "19",
"issue": "2",
"year": 1997,
"title": "A new multigene family of putative pheromone receptors.",
"URL": null,
"raw_pages": "371-9",
"medline_journal": "Neuron",
"ISO_journal": "Neuron",
"authors": [
"Ryba NJ",
"Tirindelli R."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0896-6273(00)80946-0"
},
"PUB00004309": {
"PMID": 1309649,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 1992,
"title": "A family of metabotropic glutamate receptors.",
"URL": null,
"raw_pages": "169-79",
"medline_journal": "Neuron",
"ISO_journal": "Neuron",
"authors": [
"Tanabe Y",
"Masu M",
"Ishii T",
"Shigemoto R",
"Nakanishi S."
],
"DOI_URL": "http://dx.doi.org/10.1016/0896-6273(92)90118-W"
},
"PUB00036050": {
"PMID": 10773016,
"ISBN": null,
"volume": "293",
"issue": "2",
"year": 2000,
"title": "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.",
"URL": null,
"raw_pages": "460-7",
"medline_journal": "J Pharmacol Exp Ther",
"ISO_journal": "J. Pharmacol. Exp. Ther.",
"authors": [
"Sullivan R",
"Chateauneuf A",
"Coulombe N",
"Kolakowski LF Jr",
"Johnson MP",
"Hebert TE",
"Ethier N",
"Belley M",
"Metters K",
"Abramovitz M",
"O'Neill GP",
"Ng GY."
],
"DOI_URL": "http://intl-jpet.aspetjournals.org/cgi/content/abstract/293/2/460"
},
"PUB00036049": {
"PMID": 17266540,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 2007,
"title": "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.",
"URL": null,
"raw_pages": "169-84",
"medline_journal": "Curr Drug Targets",
"ISO_journal": null,
"authors": [
"Brauner-Osborne H",
"Wellendorph P",
"Jensen AA."
],
"DOI_URL": "http://dx.doi.org/10.2174/138945007779315614"
},
"PUB00070398": {
"PMID": 17501984,
"ISBN": null,
"volume": "7",
"issue": null,
"year": 2007,
"title": "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development.",
"URL": null,
"raw_pages": "44",
"medline_journal": "BMC Dev Biol",
"ISO_journal": "BMC Dev. Biol.",
"authors": [
"Prabhu Y",
"Muller R",
"Anjard C",
"Noegel AA."
],
"DOI_URL": "http://dx.doi.org/10.1186/1471-213X-7-44"
},
"PUB00004161": {
"PMID": 8255296,
"ISBN": null,
"volume": "366",
"issue": "6455",
"year": 1993,
"title": "Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.",
"URL": null,
"raw_pages": "575-80",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Brown EM",
"Gamba G",
"Riccardi D",
"Lombardi M",
"Butters R",
"Kifor O",
"Sun A",
"Hediger MA",
"Lytton J",
"Hebert SC."
],
"DOI_URL": "http://dx.doi.org/10.1038/366575a0"
},
"PUB00005965": {
"PMID": 9069281,
"ISBN": null,
"volume": "386",
"issue": "6622",
"year": 1997,
"title": "Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.",
"URL": null,
"raw_pages": "239-46",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Kaupmann K",
"Huggel K",
"Heid J",
"Flor PJ",
"Bischoff S",
"Mickel SJ",
"McMaster G",
"Angst C",
"Bittiger H",
"Froestl W",
"Bettler B."
],
"DOI_URL": "http://dx.doi.org/10.1038/386239a0"
},
"PUB00005966": {
"PMID": 9844003,
"ISBN": null,
"volume": "95",
"issue": "25",
"year": 1998,
"title": "Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.",
"URL": null,
"raw_pages": "14991-6",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Kaupmann K",
"Schuler V",
"Mosbacher J",
"Bischoff S",
"Bittiger H",
"Heid J",
"Froestl W",
"Leonhard S",
"Pfaff T",
"Karschin A",
"Bettler B."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.95.25.14991"
},
"PUB00005967": {
"PMID": 9872316,
"ISBN": null,
"volume": "396",
"issue": "6712",
"year": 1998,
"title": "Heterodimerization is required for the formation of a functional GABA(B) receptor.",
"URL": null,
"raw_pages": "679-82",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"White JH",
"Wise A",
"Main MJ",
"Green A",
"Fraser NJ",
"Disney GH",
"Barnes AA",
"Emson P",
"Foord SM",
"Marshall FH."
],
"DOI_URL": "http://dx.doi.org/10.1038/25354"
},
"PUB00076358": {
"PMID": 17950724,
"ISBN": null,
"volume": "312",
"issue": "1",
"year": 2007,
"title": "A GPCR involved in post aggregation events in Dictyostelium discoideum.",
"URL": null,
"raw_pages": "29-43",
"medline_journal": "Dev Biol",
"ISO_journal": "Dev. Biol.",
"authors": [
"Prabhu Y",
"Mondal S",
"Eichinger L",
"Noegel AA."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.ydbio.2007.08.055"
},
"PUB00095651": {
"PMID": 18165688,
"ISBN": null,
"volume": "283",
"issue": "8",
"year": 2008,
"title": "Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor.",
"URL": null,
"raw_pages": "4665-73",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Nomura R",
"Suzuki Y",
"Kakizuka A",
"Jingami H."
],
"DOI_URL": null
},
"PUB00062692": {
"PMID": 22660477,
"ISBN": null,
"volume": "15",
"issue": "7",
"year": 2012,
"title": "Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.",
"URL": null,
"raw_pages": "970-8",
"medline_journal": "Nat Neurosci",
"ISO_journal": "Nat. Neurosci.",
"authors": [
"Geng Y",
"Xiong D",
"Mosyak L",
"Malito DL",
"Kniazeff J",
"Chen Y",
"Burmakina S",
"Quick M",
"Bush M",
"Javitch JA",
"Pin JP",
"Fan QR."
],
"DOI_URL": "http://dx.doi.org/10.1038/nn.3133"
},
"PUB00095650": {
"PMID": 24305054,
"ISBN": null,
"volume": "504",
"issue": "7479",
"year": 2013,
"title": "Structural mechanism of ligand activation in human GABA(B) receptor.",
"URL": null,
"raw_pages": "254-9",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Geng Y",
"Bush M",
"Mosyak L",
"Wang F",
"Fan QR."
],
"DOI_URL": null
},
"PUB00155083": {
"PMID": 38332368,
"ISBN": null,
"volume": "31",
"issue": "4",
"year": 2024,
"title": "Constitutive activation mechanism of a class C GPCR.",
"URL": null,
"raw_pages": "678-687",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat Struct Mol Biol",
"authors": [
"Shin J",
"Park J",
"Jeong J",
"Lam JH",
"Qiu X",
"Wu D",
"Kim K",
"Lee JY",
"Robinson CV",
"Hyun J",
"Katritch V",
"Kim KP",
"Cho Y."
],
"DOI_URL": "https://doi.org/10.1038/s41594-024-01224-7"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 9816,
"pathways": 23,
"proteins": 9816,
"proteomes": 1375,
"sets": 0,
"structural_models": {
"alphafold": 8600,
"bfvd": 1
},
"structures": 33,
"taxa": 4800
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4ms4",
"name": "Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist baclofen"
}
}
}
