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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR002352",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0006955",
"name": "immune response",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"prints": {
"PR00770": "EMAJORBASICP"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR002352",
"name": "Eosinophil major basic protein",
"type": "Family",
"children": []
},
"name": {
"name": "Eosinophil major basic protein",
"short": "Eosinophil_major_basic"
},
"description": [
{
"text": "<p>Eosinophil granule major basic protein (MBP) is a low molecular weight cationic protein present in the crystalloid core of the eosinophil granule [[cite:PUB00002461]]. It is a potent toxin for helminths and mammalian cells, and may have important roles in allergic and inflammatory reactions, it can release histamine from mast cells and damage epithelial cells of bronchial tubes. MBP is also involved in antiparasitic defence mechanisms and immune hypersensitivity reactions. The protein is a single arginine-rich polypeptide [[cite:PUB00001786]], its pro-portion being rich in glutamic and aspartic acids. It has been suggested that the protein is translated as a nontoxic precursor that protects the eosinophil from damage while it is processed through the endoplasmic reticulum to its sequestered site in the granule core toxic MBP [[cite:PUB00003105]]. The sequence of MBP has been shown to contain a C-type lectin (CTL) domain [[cite:PUB00003779]]. CTL domains are 110-130 residue motifs that appear to function as calcium-dependent carbohydrate-recognition domains [[cite:PUB00002461], [cite:PUB00001786], [cite:PUB00003105]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00002461": {
"PMID": 3410852,
"ISBN": null,
"volume": "263",
"issue": "25",
"year": 1988,
"title": "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein.",
"URL": null,
"raw_pages": "12559-63",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Wasmoen TL",
"Bell MP",
"Loegering DA",
"Gleich GJ",
"Prendergast FG",
"McKean DJ."
],
"DOI_URL": "http://intl.jbc.org/cgi/reprint/263/25/12559.pdf"
},
"PUB00001786": {
"PMID": 2323577,
"ISBN": null,
"volume": "86",
"issue": "2",
"year": 1990,
"title": "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein.",
"URL": null,
"raw_pages": "285-9",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Barker RL",
"Loegering DA",
"Arakawa KC",
"Pease LR",
"Gleich GJ."
],
"DOI_URL": "http://dx.doi.org/10.1016/0378-1119(90)90292-Y"
},
"PUB00003105": {
"PMID": 3171483,
"ISBN": null,
"volume": "168",
"issue": "4",
"year": 1988,
"title": "Acidic precursor revealed in human eosinophil granule major basic protein cDNA.",
"URL": null,
"raw_pages": "1493-8",
"medline_journal": "J Exp Med",
"ISO_journal": "J. Exp. Med.",
"authors": [
"Barker RL",
"Gleich GJ",
"Pease LR."
],
"DOI_URL": "http://dx.doi.org/10.1084/jem.168.4.1493"
},
"PUB00003779": {
"PMID": 1565101,
"ISBN": null,
"volume": "29",
"issue": "4",
"year": 1992,
"title": "Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins.",
"URL": null,
"raw_pages": "537-46",
"medline_journal": "Mol Immunol",
"ISO_journal": "Mol. Immunol.",
"authors": [
"Yoshimatsu K",
"Ohya Y",
"Shikata Y",
"Seto T",
"Hasegawa Y",
"Tanaka I",
"Kawamura T",
"Kitoh K",
"Toyoshima S",
"Osawa T."
],
"DOI_URL": "http://dx.doi.org/10.1016/0161-5890(92)90012-M"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR016187",
"name": "C-type lectin fold",
"type": "homologous_superfamily"
},
{
"accession": "IPR016186",
"name": "C-type lectin-like/link domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 3260,
"pathways": 3,
"proteins": 620,
"proteomes": 274,
"sets": 0,
"structural_models": {
"alphafold": 550,
"bfvd": 0
},
"structures": 8,
"taxa": 1007
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "1h8u",
"name": "Crystal Structure of the Eosinophil Major Basic Protein at 1.8A: An Atypical Lectin with a Paradigm Shift in Specificity"
}
}
}
