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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR002023",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0016491",
"name": "oxidoreductase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"prosite": {
"PS01099": "Respiratory-chain NADH dehydrogenase 24 Kd subunit signature"
},
"pirsf": {
"PIRSF000216": "NADH dehydrogenase [ubiquinone] (complex I), flavoprotein 2/NADH:quinone oxidoreductase (complex I), NuoE subunit"
},
"ncbifam": {
"TIGR01958": "NADH-quinone oxidoreductase subunit NuoE"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR028431",
"name": "NADP-reducing hydrogenase subunit HndA-like",
"type": "Family",
"children": [
{
"accession": "IPR002023",
"name": "NADH-quinone oxidoreductase subunit E-like",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "NADH-quinone oxidoreductase subunit E-like",
"short": "NuoE-like"
},
"description": [
{
"text": "<p>Respiratory-chain NADH dehydrogenase ([ec:7.1.1.2]) [[cite:PUB00001392]] (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 24 Kd (in mammals), which is a component of the iron-sulfur (IP) fragment of the enzyme. It seems to bind a 2Fe-2S iron-sulfur cluster. The 24 Kd subunit is nuclear encoded, as a precursor form with a transit peptide in mammals, and in Neurospora crassa.\n\nThe 24 Kd subunit is highly similar to [[cite:PUB00000637], [cite:PUB00003309]]: Subunit E of Escherichia coli NADH-ubiquinone oxidoreductase (gene nuoE) and Subunit NQO2 of Paracoccus denitrificans NADH-ubiquinone oxidoreductase.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00003309": {
"PMID": 7690854,
"ISBN": null,
"volume": "233",
"issue": "1",
"year": 1993,
"title": "The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.",
"URL": null,
"raw_pages": "109-22",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Weidner U",
"Geier S",
"Ptock A",
"Friedrich T",
"Leif H",
"Weiss H."
],
"DOI_URL": "http://dx.doi.org/10.1006/jmbi.1993.1488"
},
"PUB00000637": {
"PMID": 1445936,
"ISBN": null,
"volume": "1140",
"issue": "2",
"year": 1992,
"title": "Conservation of sequences of subunits of mitochondrial complex I and their relationships with other proteins.",
"URL": null,
"raw_pages": "105-34",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Fearnley IM",
"Walker JE."
],
"DOI_URL": "http://dx.doi.org/10.1016/0005-2728(92)90001-I"
},
"PUB00001392": {
"PMID": 2029890,
"ISBN": null,
"volume": "197",
"issue": "3",
"year": 1991,
"title": "The respiratory-chain NADH dehydrogenase (complex I) of mitochondria.",
"URL": null,
"raw_pages": "563-76",
"medline_journal": "Eur J Biochem",
"ISO_journal": "Eur. J. Biochem.",
"authors": [
"Weiss H",
"Friedrich T",
"Hofhaus G",
"Preis D."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1432-1033.1991.tb15945.x"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036249",
"name": "Thioredoxin-like superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR041921",
"name": "NADH-quinone oxidoreductase subunit E, N-terminal",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 24764,
"pathways": 9,
"proteins": 24760,
"proteomes": 14151,
"sets": 0,
"structural_models": {
"alphafold": 19553,
"bfvd": 0
},
"structures": 373,
"taxa": 27093
},
"entry_annotations": {},
"cross_references": {
"prositedoc": {
"displayName": "PROSITE Doc",
"description": "PROSITE is a database of protein families and domains.",
"rank": 18,
"accessions": [
{
"accession": "PDOC00843",
"url": "http://prosite.expasy.org/PDOC00843"
}
]
},
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp1751",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1751"
},
{
"accession": "GenProp1254",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1254"
},
{
"accession": "GenProp1608",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1608"
},
{
"accession": "GenProp1583",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1583"
},
{
"accession": "GenProp1198",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1198"
},
{
"accession": "GenProp1230",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1230"
},
{
"accession": "GenProp1637",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1637"
},
{
"accession": "GenProp1537",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1537"
},
{
"accession": "GenProp1341",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp1341"
},
{
"accession": "GenProp0135",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0135"
}
]
},
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "7.1.1.-",
"url": "https://enzyme.expasy.org/EC/7.1.1.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "6q9c",
"name": "Crystal structure of Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE and NuoF bound to NADH under anaerobic conditions"
}
}
}
