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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR001534",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0009986",
"name": "cell surface",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF01060": "Transthyretin-like family"
},
"panther": {
"PTHR21700": "TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001534",
"name": "Transthyretin-like",
"type": "Family",
"children": []
},
"name": {
"name": "Transthyretin-like",
"short": "Transthyretin-like"
},
"description": [
{
"text": "<p>Transthyretin-related proteins form a nematode-specific expanded protein family that comprises 59 members, 54 of which are predicted to be secreted. The proteins show weak similarity to transthyretin (formerly called prealbumin) which transports thyroid hormones. [[cite:PUB00001984]]. Some transthyretin-related genes are induced in response to environmental challenges such as oxidative stress or pathogen exposure. These proteins possess 4 cysteine residues that are conserved within the C. elegans transthyretin-related protein family, which could serve as reactive oxygen sensors or scavengers [[cite:PUB00093975]].</p>\n<p>Transthyretin-related protein 52 (TTR-52), a member of this family, is required for efficient cell corpse engulfment by the recognition the surface exposed phosphatidylserine (PS). TTR-52 mediates recognition of apoptotic cells by cross-linking the PS signal with the phagocyte receptor CED-1 [[cite:PUB00088242]].</p>",
"llm": false,
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],
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"literature": {
"PUB00001984": {
"PMID": 9417907,
"ISBN": null,
"volume": "46",
"issue": "2",
"year": 1997,
"title": "Analysis of protein domain families in Caenorhabditis elegans.",
"URL": null,
"raw_pages": "200-16",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Sonnhammer EL",
"Durbin R."
],
"DOI_URL": "http://dx.doi.org/10.1006/geno.1997.4989"
},
"PUB00088242": {
"PMID": 20526330,
"ISBN": null,
"volume": "12",
"issue": "7",
"year": 2010,
"title": "Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.",
"URL": null,
"raw_pages": "655-64",
"medline_journal": "Nat Cell Biol",
"ISO_journal": "Nat. Cell Biol.",
"authors": [
"Wang X",
"Li W",
"Zhao D",
"Liu B",
"Shi Y",
"Chen B",
"Yang H",
"Guo P",
"Geng X",
"Shang Z",
"Peden E",
"Kage-Nakadai E",
"Mitani S",
"Xue D."
],
"DOI_URL": "https://doi.org/10.1038/ncb2068"
},
"PUB00093975": {
"PMID": 29346382,
"ISBN": null,
"volume": "14",
"issue": "1",
"year": 2018,
"title": "6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.",
"URL": null,
"raw_pages": "e1007125",
"medline_journal": "PLoS Genet",
"ISO_journal": "PLoS Genet.",
"authors": [
"Offenburger SL",
"Ho XY",
"Tachie-Menson T",
"Coakley S",
"Hilliard MA",
"Gartner A."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR038479",
"name": "Transthyretin-like superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 134,
"interactions": 0,
"matches": 5680,
"pathways": 0,
"proteins": 5415,
"proteomes": 114,
"sets": 0,
"structural_models": {
"alphafold": 5026,
"bfvd": 0
},
"structures": 1,
"taxa": 344
},
"entry_annotations": {
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"alignment:full": 3950
},
"cross_references": {},
"is_llm": false,
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"representative_structure": null
}
}
