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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR001087",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0016788",
"name": "hydrolase activity, acting on ester bonds",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF00657": "GDSL-like Lipase/Acylhydrolase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001087",
"name": "GDSL lipase/esterase",
"type": "Family",
"children": [
{
"accession": "IPR035669",
"name": "GDSL lipase/esterase-like, plant",
"type": "Family",
"children": [
{
"accession": "IPR044552",
"name": "GDSL esterase/lipase GLIP1-5/GLL25",
"type": "Family",
"children": []
}
]
}
]
},
"name": {
"name": "GDSL lipase/esterase",
"short": "GDSL"
},
"description": [
{
"text": "<p>GDSL esterases and lipases are hydrolytic enzymes with multifunctional properties [[cite:PUB00033179]]. This new subclass of lipolytic enzymes possesses a distinct GDSL sequence motif different from the GxSxG motif found in many lipases [[cite:PUB00005440]]. Members include; Aeromonas hydrophila lipase, Vibrio mimicus lecithinase, Vibrio parahaemolyticus thermolabile haemolysin, rabbit phospholipase (AdRab-B), and Arabidopsis thaliana anter-specific proline-rich protein. 3D structures of several enzymes of this family revealed several β-strands and α-helices arranged in alternating order and the substrate-binding pocket between the central β-strand and long α-helix appears to be highly flexible [[cite:PUB00095657]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00005440": {
"PMID": 7610479,
"ISBN": null,
"volume": "20",
"issue": "5",
"year": 1995,
"title": "A new family of lipolytic enzymes?",
"URL": null,
"raw_pages": "178-9",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Upton C",
"Buckley JT."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0968-0004(00)89002-7"
},
"PUB00033179": {
"PMID": 15522763,
"ISBN": null,
"volume": "43",
"issue": "6",
"year": 2004,
"title": "GDSL family of serine esterases/lipases.",
"URL": null,
"raw_pages": "534-52",
"medline_journal": "Prog Lipid Res",
"ISO_journal": "Prog. Lipid Res.",
"authors": [
"Akoh CC",
"Lee GC",
"Liaw YC",
"Huang TH",
"Shaw JF."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.plipres.2004.09.002"
},
"PUB00095657": {
"PMID": 19555778,
"ISBN": null,
"volume": "1791",
"issue": "11",
"year": 2009,
"title": "Identification and biochemical characterization of a GDSL-motif carboxylester hydrolase from Carica papaya latex.",
"URL": null,
"raw_pages": "1048-56",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
"authors": [
"Abdelkafi S",
"Ogata H",
"Barouh N",
"Fouquet B",
"Lebrun R",
"Pina M",
"Scheirlinckx F",
"Villeneuve P",
"Carriere F."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036514",
"name": "SGNH hydrolase superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 1088,
"interactions": 0,
"matches": 81516,
"pathways": 33,
"proteins": 78421,
"proteomes": 7959,
"sets": 0,
"structural_models": {
"alphafold": 66858,
"bfvd": 4
},
"structures": 63,
"taxa": 17374
},
"entry_annotations": {
"alignment:seed": 67,
"alignment:full": 45176
},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.1.1",
"url": "https://enzyme.expasy.org/EC/3.1.1"
},
{
"accession": "3.1.1.-",
"url": "https://enzyme.expasy.org/EC/3.1.1.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "8hwp",
"name": "Crystal Structure of Mutant GDSL Esterase of Photobacterium sp. J15 S12A in Complex with Butyrate"
}
}
}
